A Study On Relationship Between TCM Syndrome Differentiation And Microsatellite Instability In Left And Right Colon Cancer

Objective:To observe the differences between the left and right colon cancer and to explore the differences in the distribution of TCM syndromes.At the same time,the correlation between left and right colon cancer and its TCM syndromes and microsatellite instability was also discussed.Methods:In this study,70 cases of right colon cancer and 70 cases of left colon cancer were admitted to the general surgery department of the second people's hospital of fujian province on February 1,2019 and December 31,2019.The dividing line of left and right was the junction of the proximal transverse colon at 2/3 and the distal transverse colon at 1/3.After admission,information was collected,including information of the four TCM diagnoses,gender and age.Postoperative pathological information was collected,including gross pathological classification of the mass,histological and pathological types,clinical TNM staging,microsatellite instability and other indicators.The collected data were collected and analyzed by statistical software to observe the distribution pattern of TCM syndromes of left and right colon cancer.By using chi-square test and other statistical methods,the relationship between TCM syndromes of left and right colonic cancer and TNM staging,microsatellite instability and other factors was analyzed.Results:1.There was no significant difference in gender,age or TNM stage between left and right colon cancer patients(P > 0.05).2.There were differences in the general pathological type,histopathological type and microsatellite instability of the left and right colon cancer remission(P < 0.05).The left colon cancer was mainly ulcerated and moderately differentiated adenocarcinoma,while the right colon cancer was mainly uplifted,moderately differentiated and specialized adenocarcinoma.Microsatellite instability was more common in the right colon cancer(18.6%vs7.1%,P <0.05).3.The number of cases in patients with left colon cancer was successively from most to less: dampness and heat accumulate syndrome(52.9%)> qi stagnation and blood stasis syndrome(15.7%)> liver and kidney Yin deficiency syndrome(11.4%)> qi and blood deficiency syndrome(10.0%)> spleen and kidney Yang deficiency syndrome(10.0%).In the right colon cancer patients,the number of cases from most to less is as follows: liver and kidney Yin deficiency syndrome(27.1%)> qi and blood deficiency syndrome(24.3%)>dampness and heat accumulate syndrome(22.9%)> qi stagnation and blood stasis syndrome(15.7%)> spleen and kidney Yang deficiency syndrome(10.0%).There were statisticallysignificant differences in the distribution of TCM syndromes in the left and right colon cancer(P < 0.05).The left colon cancer was mainly manifested by dampness and heat accumulating syndrome and qi stagnation and blood stasis syndrome,while the right colon was mainly manifested by liver and kidney Yin deficiency syndrome and qi and blood deficiency syndrome(P < 0.05).4.There was a correlation between TCM syndromes of colon cancer and TNM staging(P < 0.05).? period,? period is given priority to with empirical;Stage ?,? see more patients with deficiency syndrome(P < 0.05).5.Microsatellite instability was more common in right colon cancer(18.6% vs 7.1%,P <0.05).6.Microsatellite instability is related to TCM syndrome type of colon cancer.Microsatellite instability is mainly found in Qi stagnation and blood stasis syndrome,damp heat accumulation syndrome and Qi and blood deficiency syndrome.(P <0.05)?7.There was no difference in the distribution of TCM syndromes in the left and right colon cancer of microsatellite instability phenotypes(P > 0.05).There was no difference in the distribution of TCM syndromes in the left and right colon cancer of microsatellite instability phenotype(P > 0.05).Conclusion:1.The pathology of the left colon cancer was mainly ulcerative and moderately differentiated adenocarcinoma,while the right colon cancer was mainly uplifted,moderately differentiated adenocarcinoma and specialized adenocarcinoma.2.The left colon cancer is mainly manifested by dampness and heat accumulating syndrome,qi stagnation and blood stasis syndrome,etc.The right colon is characterized by deficiency of liver and kidney Yin and deficiency of qi and blood.3.? period,see more damp and hot accumulate knot stage ? colon cancer syndrome,qi and blood stasis and other empirical;? period,see more stage ? colon cancer liver and kidney Yin deficiency syndrome,qi two kui deficiency syndrome,etc.4.Microsatellite instability is more common in right colon cancer.5.Microsatellite instability mainly occurs in Qi stagnation and blood stasis syndrome,dampness heat accumulation syndrome and Qi blood deficiency syndrome.However,there is no difference in the distribution of TCM syndrome types between left and right colon cancer with microsatellite instability phenotype.