Study On The Value Of Anti-factor Xa Activity Test In The Management And Monitoring Of Blood Loss, Ecchymosis Formation And Blood Coagulation After Total Knee Arthroplasty

Objective: To explore the value of anti-Xa factor activity in predicting bleeding events after total knee arthroplasty(TKA),to explore the relationship between bleeding events and hidden blood loss after TKA,to find the risk factors for ecchymosis after TKA Provide the basis and ideas for the design of individual anticoagulation plan during the perioperative period of replacement.Methods: All patients who received initial TKA treatment in our department were treated with rivaroxaban anticoagulation after operation.They were divided into two groups according to whether ecchymosis occurred in the perioperative period: ecchymosis group and non-ecchymosis group.Observe and record the perioperative thrombosis,bleeding events and complications of patients.The main laboratory indicators include: anti-Xa factor activity,hemoglobin,prothrombin time(PT),activated partial thromboplastin time(APTT),thrombus elasticityFigure(TEG).Compare and analyze the difference of blood loss and coagulation function between the two groups of patients after operation.Results: A total of 102 patients were included,including 28 in the ecchymosis group and 74 in the non-ecchymosis group.The anti-Xa activity of the ecchymosis group and the non-ecchymosis group was different on the 1st and 3rd day after operation(P <0.05).Higher perioperative total blood loss,invisible blood loss and incidence of postoperative complications were found in the ecchymosis group than non-ecchymosis group(P < 0.05).There was no obvious difference in the residual coagulation index.n regression analysis,anti-Xa factor activity was found to be a risk factor for the formation of ecchymosis after TKA.Conclusion: Anti-Xa factor activity is an independent risk factor for the formation of ecchymosis after TKA,which provides a basis for stopping or reducing the amount of medication after ecchymosis after TKA.The formation of ecchymosis after TKA is related to the increase of invisible blood loss after operation.Patients with ecchymosis may be more prone to incision complications.