Effect Of Short-term Rehabilitation On Blood Hypercoagulable State In Patients With Acute Ischemic Stroke

Background: The blood of patients with cerebral infarction is mostly in the state of hypercoagulability or hyperfibrinolysis,which is prone to recurrent adverse events such as thrombus and infarction,which affect the prognosis of the patients.Drug therapy is an important means to reduce the hyperfibrinolytic state in patients with cerebral infarction,but drug resistance,individual drug gene polymorphism and adverse drug reactions often lead to poor drug prevention and treatment.At the same time,antithrombotic therapy is difficult for patients with infarction complicated with bleeding or high risk of bleeding.Therefore,it is necessary to further explore safe and effective treatment as an alternative to drug intervention or appropriate adjuvant therapy,in order to achieve the best preventive effect.The study found that aerobic exercise can effectively ease the blood hypercoagulable state of patients with ischemic stroke,but the subjects selected in this study are patients with convalescent cerebral infarction,and the coagulation system of patients with acute ischemic stroke is more prone to abnormality.Therefore,the intervention measures for the acute phase aremore important.In this study,we observed the effect of short-term rehabilitation on blood hypercoagulable state in patients with acute ischemic stroke,in order to provide references and suggestions for the prevention and treatment of cerebral infarction.Objective: The effect of short-term rehabilitation on blood hypercoagulability in patients with acute cerebral infarction was observed carefully.Methods: A retrospective study was conducted on 133 patients with acute ischemic stroke who met the inclusion criteria in our hospital from September 2017 to November 2018.They were divided into treatment group(n=100)and control group(n=33)on the basis of whether they received early rehabilitation or not.After one week of treatment,compared the differences of blood coagulation indexes between after treatment and before treatment in the group.Besides,according to different treatment methods,the control group was divided into subgroup such as aspirin group(n=12),clopidogrel group(n=10)and double antibody group(aspirin combined with clopidogrel)group(n=11).The treatment group was divided into subgroup such as aspirin + rehabilitation group(n=45),clopidogrel +rehabilitation group(n=21)and double antibody + rehabilitation group(n=34).Compared the decrease of fibrinolysis related indexes after one week of treatment.Results: Baseline data(time of onset,sex,age,neurological deficitscore,body mass index,glycosylated hemoglobin,total cholesterol,triglyceride,low density lipoprotein cholesterol)and initial coagulation indexes between the two groups were compared absolutely and importantly,with no significant(P >0.05).Behind one week rehabilitation treatment,fibrin degradation products,thrombin time,D-dimer and the prothrombin time in the experimental group were importantly and absolutely below that before treatment(P<0.05),while fibrinogen was absolutely higher than those before the training(P<0.05),other coagulation indexes between the two groups shows no absolutely difference(P >0.05).FDP,D-D and FIB in the control group were importantly higher than the initial level,while TT was importantly below the initial level(P >0.05),with no absolute difference in other coagulation and fibrinolytic related indicators(P >0.05).The study on the changing trend of fibrinolysis index shows that,the FIB of the patients in the two group increased gradually after one week of training,but the increase of FIB in the treatment group below that in the control group,with no important difference(P>0.05).D-D and FDP in the NC group showed an increasing trend,however,the experimental group showed a down momentum(P<0.05).The probability of lower limb venous thrombosis in the treatment group below that in the contrast group,the result between the two groups showed no absolute difference(P>0.05).Conclusion: Acute phase of cerebral infarction implemented short-term rehabilitation is safe,and short-term rehabilitation can ease the highcoagulation state of the blood system of patients,or be good for reducing lower limb venous thrombosis during hospitalization.