The Influence Of Drug-coated Central Vein Catheter On Catheter-associated Deep Venous Thrombosis

Objective: The use of drug-coated central venous catheters can significantly reduce the incidence of long-term central venous catheter-related bloodstream infections.However,the surface of the drug-coated central venous catheter is rougher than the common central venous catheter,which may increase the risk of catheter-related deep vein thrombosis.At present,there are few clinical studies on drug-coated central venous catheters for catheter-related thromboembolic complications.Therefore,this study is a large-scale prospective randomized controlled clinical study to investigate whether venous catheterization of drug-coated central venous catheters increases CADVT.It will help to improve the safety of perioperative period and improve the prognosis of patients.It should be of great significanceMethods: Collecting 1013 patients who underwent central venous catheterization in our hospital during the period of 2017.12~2018.12.Patients were screened according to inclusion and exclusion criteria,and were randomly divided into the general common central venous catheterization group(Cont group)and the drug-coated central venous catheterization group(AntiM group).Handheld ultrasound machine was used for follow-up and evaluation of the incidence and extent of CADVT within 7 days after catheterization in both groups.Subgroup analysis of gender,age,ASA classification,Caprini score for thrombus risk,ultrasound-guided catheterization,and anticoagulant therapy,Collect and record catheter related complications,including mechanical and infection complications.Intent-to-treat(ITT)was used to evaluate the difference in the incidence of CADVT-related indicators between the two groups by odd ratios(ORs)and their 95% confidence interval(CI).Results: The demographic data of the two groups were similar,2 patients were lost to the hospital due to transfer,and the remaining 1011 patients were followed up.There was no significant difference in the incidence of CADVT between the two groups(Cont vs.AntiM: 8.4% vs.7.6%;OR 0.91,95% CI 0.57 to 1.43);Subgroup analysis suggested that there was no significant difference in the incidence of CADVT between the two groups in terms of gender(male:OR 1.06,95% CI 0.59~1.89;female:OR 0.65,95% CI 0.30~1.41),age(<65years old:OR 1.08,95% CI 0.59~1.96;?65years old:OR 0.70,95% CI 0.34~1.43),Caprini score(Low to medium risk(0~4 points):OR 0.39,95% CI 0.09~1.77;High risk(?5 points:OR 0.96,95% CI 0.59~1.55),such as ultrasound-guided catheterization,(yes:OR 0.38,95% CI 0.03~4.87;No:OR 0.93,95% CI 0.59~1.49)or anticoagulant therapy(yes :OR 1.61,95% CI 0.46~5.68;No:OR 0.83,95% CI 0.51~1.37).No serious adverse events occurred in either group.Conclusion: Drug-coated central venous catheter does not increase thrombus rate within 7 days of catheter indwelling.