Detection And Clinical Meaning Of Serum Neuron-specific Enolase And High-sensitivity C-reactive Protein In Patients With Special Severe Craniocerebral Injury And Severe Craniocerebral Injury

Objective To investigate the changes and analysis of serum levels of NSE and hs-CRP in patients with special severe craniocerebral injury and severe craniocerebral injury.Methods According to the inclusion criteria,patients with severe craniocerebral injury who visited the neurosurgery department of Gansu Provincial People's Hospital and the neurosurgery department of Gansu Second People's Hospital from January 2019 to October 2019 were selected as the case study subjects.Healthy volunteers who underwent physical examination in both hospitals during the same period were selected as the normal control group,and the expression levels of serum NSE and hs-CRP were detected on the 1st,4th and 7th days after admission in each group.According to the Glasgow Coma Score(GCS)at the time of treatment,the patients were divided into very severe and severe,and the results of serum NSE and hs-CRP were compared between the two groups of patients with craniocerebral injury;according to the results of CT examination,the patients were divided into three groups according to the type of injury: subdural hematoma,epidural hematoma,brain contusion and laceration and(or)intracerebral hematoma,and the serum of the three groups was compared.The levels of NSE and hs-CRP were measured to explore the relationship between the levels of NSE and hs-CRP and the types of severe craniocerebral injury.Results The serum levels of NSE and hs-CRP in patients with severe and extra-severe craniocerebral trauma were significantly higher than those in the control group.The difference was statistically significant(P<0.05),and the serum NSE level of patients with severe craniocerebral injury was significantly higher than that of patients with severe craniocerebral injury,the difference was statistically significant(P<0.05),while the serum hs-CRP level was not significantly different between the severe group and the severe group(P<0.05);the serum NSE content of patients with three different types of craniocerebral injury was significantly different(P<0.05).However,there was no significant difference in serum hs-CRP levels among the three different types of brain injury(P<0.05).Conclusion Increased serum NSE and hs-CRP levels at the beginning of admission in patients with craniocerebral injury are associated with the occurrence of the disease.Serum NSE can be used as an objective laboratory index to judge the severity of severe craniocerebral injury,the higher its content,suggesting that the severer the degree of brain injury;NSE can also be used as a specific index for early auxiliary evaluation of severe craniocerebral injury types;compared with hs-CRP,NSE has more reference value for the diagnosis of different types of craniocerebral injury.