Changes Of Plasma IGF-1,NPY And BAP During Perioperative Period In Diabetic Patients With Fracture

Objective:To study the changes of perioperative plasma levels of insulin-like growth factor-1(IGF-1),neuropeptide Y(NPY)and bone alkaline phosphatase(BAP)in diabetic patients with fracture,and to explore their effects on fracture healing in diabetic patients.Methods:Seventy patients with lower limb fracture surgery under selective subarachnoid anesthesia from September 2018 to March 2019 were selected.According to whether there was type 2 diabetes,they were divided into the diabetes group and the control group,with thirty-five patients in each group.Two milliliter of elbow-vein blood was extracted pre-operation and 24 hours after surgery,respectively.Plasma was separated and the contents of IGF-1,NPY and BAP in plasma were determined by enzyme linked immunosorbent assay(ELISA).Results:The plasma levels of IGF-1,NPY and BAP were significantly higher at 24 hours after surgery than before surgery in the diabetic group and the control group(P<0.05).The plasma level of IGF-1 in diabetic group was lower than that in control group before and after surgery(P<0.05).Before surgery,the plasma NPY and BAP levels were significantly higher than that of control group(P<0.05).After surgery,the increase of NPY in plasma was significantly lower in the diabetic group than that in the control group(P<0.05).Conclusion:IGF-1,NPY and BAP are all involved in the regulation of bone healing repair process.The decrease of IGF-1,the smaller degree of NPY increase and the continuous increase of BAP may be related to delayed bone healing during early stage after fracture surgery indiabetic patients.