Application Of OCTA Quantitative Analysis In Prognosis Evaluation Of Branch Retinal Vein Occlusion

Objective:To observe the fundus perfusion in patients with branch retinal vein occlusion(BRVO)by using optical coherence tomography angiography(OCTA),and to analyze the correlation between visual acuity.Methods:Retrospective study.30 patients with monocular BRVO and 15 normal controls with 30 eyes were included in the study.we examined all patients with unilateral RVOs and normal individuals of a control group by using optical coherence tomography angiography(OCTA).The change of FAZ area,superficial and deep vascular density,FD(Foveal vascular density in a 300?m wide region around FAZ)and macular fovea thickness were compared between eyes with retinal vein occlusions and the contralateral unaffected eyes,the contralateral unaffected eyes and control group.And Analyze the relationship between the FAZ area,vascular density,FD and macular fovea retinal thickness with the BCVA(LogMAR)in patients with unilateral RVOs.Results:30 patients with BRVO were enrolled,including 22 eyes with temporal superior branch vein occlusion(73%)and 8 eyes with temporal inferior branch vein occlusion(27%).The FAZ area in BRVO eyes significantly increased compared to the contralateral(0.298±0.145mm~2 vs 0.247±0.089mm~2,P<0.05),there is no significant difference in FAZ area between the contralateral and the normal eyes(0.247±0.089 mm~2 vs 0.268±0.052mm~2,P>0.05),and FAZ area was positively correlated with BCVA of BRVO eyes.(r=0.610,P=0.0003).The vascular density in BRVO eyes significantly decreased compared to the contralateral eyes(SVD:WholeImage:42.5±4.7%vs 47.3±4.6%,P>0.05;ParaFovea:43.1±5.2%vs48.7±7.7%,P<0.05;PeriFovea:43.0±4.9%vs 47.8±4.9%,P<0.05;DVD:WholeImage:44.0±4.8%vs 50.2±6.2%,P<0.05;ParaFovea:47.6±5.4%vs 54.3±5.6%,P<0.05;PeriFovea:45.0±5.7%vs 51.1±6.8%,P<0.05;FD:48.5±5.5%vs 52.3±4.8%,P<0.05),and the FD was correlated negatively with the BCVA of BRVO eyes.(r=-0.453,P=0.012).The vascular density in the contralateral eyes also significantly decreased compared to the normal eyes(SVD:WholeImage:47.3±4.6%vs51.4±3.1%,P<0.05;ParaFovea:48.7±7.7%vs 53.4±5.2%,P<0.05;PeriFovea:47.8±4.9%vs 52.2±3.1%,P<0.05;DVD:WholeImage:50.2±6.2%vs 55.5±3.9%,P<0.05;ParaFovea:54.3±5.6%vs 58.0±2.9%,P<0.05;PeriFovea:51.1±6.8%vs57.0±4.2%,P<0.05;FD:52.3±4.8%vs 56.3±4.0%,P<0.05).The macular foveal retinal thickness in BRVO eyes significantly increased compared to the contralateral(379±122?m vs 240±22?m,P<0.05),there is no significant difference in the macular foveal retinal thickness between contralateral and normal eyes(240±22?m vs238±14?m,P>0.05),and correlated positively with the BCVA in BRVO eyes.Conclusions:OCTA can be used to quantitatively analyze the FAZ area,blood perfusion and retinal thickness of macular fovea in BRVO patients.OCTA can be used to measure the FAZ area,blood perfusion and retinal thickness of macular fovea in BRVO patients,which can be used to evaluate the treatment and prognosis of BRVO.Decreased vessel density may be an indicator of early changes in retinal vascular diseases.