EOB-MRI To Predict MVI In Hepatocellular Carcinoma

Objective: The purpose of this study is to predict the risk of MVI in patients through preoperative clinical examination and relevant data presented in eob-mri imaging examination,and to establish a prediction model that can be used in clinical work.Methods: We retrospectively collected 157 patients with single HCC.All the enrolled patients underwent surgical resection of liver cancer in our hospital,and the pathological data were complete.Eob-MRI examination was performed preoperatively.We will according to the results of patients with postoperative pathologic MVI negative or MVI positive,divided into two groups,two common analysis of all the patients with preoperative imaging physicians EOB-MRI imaging information,which includes the tumor diameter,shape(edge),peritumor enhancement,peritumor hypointensity,tumor capsule,magnetic resonance diffusion weighted imaging(DWI).The physicians in the undergraduate department collected all patients’ laboratory examinations and postoperative pathological stages of tumors,and found out the risk factors of MVI by comparing the data of the two groups.At the same time,considering that the lesion size is too small,which will have an impact on the diagnosis of EOB-MRI,we divided the patients into two groups with diameter >3cm and ≦3cm by tumor diameter and conducted statistical analysis on them respectively.Results: According to the pathological results of 157 cases of lesions,97 cases were positive for MVI,including 77 cases with M1(less than or equal to 5 MVI)and 20 cases with M2(more than 5 MVI).Single factor analysis: the tumor diameter,peritumor enhancement,tumor capsule,peritumor hypointensity,liver cancer,postoperative pathologic differentiation degree of tumor are associated with MVI,multi-factor logistic analysis hint: tumor diameter(P = 0.035),liver tumor around low signal(P = 0.026),membrane integrity(P < 0.001)are associated with MVI.The sensitivity and specificity of MVI were 77.3% and 85.1% respectively.After grouping,the tumor diameter ≦3cm in the group,and univariate analysis suggested that capsule integrity and peritumor hypointensity were related to the occurrence of MVI.Multivariate logistic analysis suggested that l peritumor hypointensity(P=0.016)in hepatobiliary stage was an independent risk factor for MVI.After grouping,the tumor diameter > 3cm in the group.Univariate analysis indicated that whether the patient had a history of hepatitis B,high signal around arterial stage tumor,capsule integrity,peritumor hypointensity,and postoperative pathological differentiation of the tumor were related to the occurrence of MVI.Multivariate logistic analysis indicated that whether the patient had a history of hepatitis b(P=0.024),capsule integrity(P < 0.001),and peritumor hypointensity(P=0.049)were independent risk factors for the occurrence of MVI.Conclusion: Tumor diameter,peritumor hypointensity,and capsule integrity were independent risk factors for the occurrence of MVI regardless of tumor diameter.However,when the tumor diameter ≦3cm,l peritumor hypointensity was an independent risk factor for MVI.When the tumor diameter > 3cm,whether the patient has a history of hepatitis b,capsule integrity,and peritumor hypointensity are independent risk factors for MVI.