Plane-wave Based 3D Ultrasound Imaging Method And Its Applications In Primate Brain Imaging

Cerebrovascular disease means the cerebral dysfunction.It is one of the three major diseases that seriously threaten human health.In 2018,cerebrovascular diseases accounted for 20.52% of deaths among urban residents.Its serious harm not only lies in its high morbidity,high fatality rate and high disability rate,but also high recurrence rate.Accurate diagnosis and treatment of diseases is very important.Currently,the detection methods in medical imaging include digital subtraction angiography(DSA),magnetic resonance angiography and transcranial Doppler ultrasound.Taking DSA as an example,although it may clearly show the condition of blood vessels,it is expensive,and it needs contrast agent,which may cause some serious complications and fail to detect the blood flow velocity.It will be helpful to the clinical disease for providing hemodynamic parameters.Ultrasound has the advantages of safety,low cost and portability.In recent years,ultra-fast ultrasound imaging sequences have further improved the sensitivity,and the imaging frame rate has been greatly improved,which offers a new way for ultrasound blood flow imaging.Ultrasound Doppler blood flow image can provide hemodynamic parameters,which is expected to provide new reference data for the diagnosis of clinical vascular diseases.Compared with other functional brain imaging methods,the planewave ultrasound imaging based on ultra-fast imaging architecture has higher spatial and temporal resolution and can show the instantaneous changes of tiny blood vessel volume.At present,two-dimensional Doppler flow imaging algorithm based on plane wave has made great progress and has been widely used in carotid artery,liver and cerebral blood flow.However,the spatial information in the imaging field cannot be obtained by two-dimensional images alone.So this paper proposes a 3D ultrasound imaging method of blood flow based on plane wave.The combination of those can provide more useful vascular information and provide a valuable imaging tool for the diagnosis of vascular diseases.In this paper,the first step was to study the plane wave microflow ultrasound imaging algorithm,and the SVD filter is studied and improved to obtain a better 2D micro-flow image.Furthermore,we combined ultra-fast ultrasound plane wave imaging technology with 3d imaging technology,and designed a rotating 3D ultrasonic acquisition device,so that we can obtain 3D images by 3D reconstruction algorithm through multi-group 2D images obtained by linear array probe.We have conducted brain imaging studies in primates based on developed imaging method and system.First in experimental animals of the primary visual cortex area of surgical operation records windows installation,then using programmable ultrasonic platform,15 MHZ linear array ultrasonic primates of the primary visual cortex for Doppler blood flow collection,obtained the good 3D cylindrical blood flow images,can be more intuitive to observe blood flow distribution record window area,get more info about the brain.Since brain function is closely related to brain blood flow,we collected and analyzed hemodynamic parameters through visual stimulation in awake primates,and found that there has some relationship between blood flow changes in primary visual cortex and stimulation patterns.Three-dimensional ultrasound imaging method based on plane wave can better display the distribution of tiny blood vessels and Doppler blood flow changes in space,which is a valuable blood flow imaging tool and is expected to provide a convenient imaging tool for the diagnosis of vascular diseases.