EEG Analysis Of Pediatric Propofol Mcfarlan Manual Infusion Regimen

Objective:To monitor the depth of anesthesia using propofol Mc Farlan intravenous infusion regime during general anesthesia in children aged 3 to 11 years using a brain function monitor.Methods:Frontal EEG recording were obtained from41children(3~11yr)during propofol anaesthesia using Mc Farlan infusion regimen,two minutes EEG data segments were taken every fifteen minutes,the first EEG data segment was taken ten minutes after induction.The 2min EEG data segments collected were labeled T1,T2,T3,T4,T5,T6,T7 and T8.All children collected at least four EEG data segments at T1,T2,T3 and T4 time points.T1,T2 correspond to propofol infusion rates of 15mg?kg-1?h-1(0-15min)and 13mg?kg-1?h-1(15-30min),respectively;T3 and T4 correspond to propofol infusion rates were 11mg?kg-1?h-1(30-45 min,45-60min);T5,T6,T7,T8 correspond to propofol infusion rates were 10mg?kg-1?h-1(60-120min).Collect the EEG data segments of 10 min,20min,and 30 min after stopping the infusion of propofol in children,Monitor the vital signs of children during operation,count the types of adverse events during operation and record the recovery time of children after stopping infusion.Results:In Mc Farlan manual infusion regime,children's frontal EEG shows slow,delta,alpha,and beta oscillations.The median frequency of children is mainly in the delta band.The spectral edge frequency is in beta band.During anesthesia maintenance,the beta band appears and its power ratio is greater than the alpha band power ratio.The depth of pediatric anesthesia was not stable with the propofol Mc Farlan infusion protocol.In the first 60 minutes of infusion,although the infusion rate was gradually decreased,the state of pediatric anesthesia gradually deepened and did not reach a sustained stable state.With the increase of propofol infusion time,the total power of children's EEG decreased,and there was no significant difference in the power ratio of various bands,and the anesthesia became shallow.When propofol stopped infusion,the total power of EEG decreased rapidly.and the power of slow,delta,and alpha bands decreased first,and the power of beta band increased.With the extension of the time of stopping the infusion,the total power of EEG continues to decrease,the power ratio of beta band decreases,and the power ratio of slow and delta band increases.At the same time,the theta band appears,showing a low power EEG mode.There was no statistical significance in the change of the patient state index(PSI)in the whole anesthesia process,which could not accurately reflect the change of children's anesthesia depth.There was no significant relationship between the infusion time of propofol and the recovery time of anesthesia in children.Conclusion:In Mc Farlan manual infusion regimen Chinese children's frontal EEG shows slow,delta,alpha,and beta oscillations,and the anesthesia program can not maintain a stable depth of anesthesia for children.With the change of time,the anesthesia state of children deepens first and then becomes shallow.There was no significant relationship between the duration of intravenous infusion of propofol and the duration of anesthesia recovery in children.This mode of intravenous infusion does not lead to deep anesthesia in children and prolonged anesthesia recovery.This anesthesia protocol for propofol has certain feasibility in clinical pediatric anesthesia.