Clinical Analysis Of Patients With Allergic Rhinitis-asthma Syndrome In Ningxia

Objective: Analysis of clinical characteristics of combined allergic rhinitis and asthma syndrome(CARAS)in Ningxia area,to study the clinical correlation between the two and investigate the cognitive status and treatment status of CARAS patients,while paying attention to the recurrence,prognosis and follow-up of patients.Methods: To collect medical records of Ningxia Medical University General Hospital and Ningxia Medical University Cardiocerebral Vascular Hospital from September 12,2018 to October 1,2018.The medical records of patients diagnosed with asthma in the emergency department were divided into CARAS group and simple asthma(SA)group.By recording the gender,age,family,history,smoking history,allergic history,regional distribution,and body mass index(BMI),the course of asthma,the course of rhinitis,the initial or relapse,the severity of asthma of the two groups of patients,the eosinophil percentage(EOS%)and absolute eosinophil(EOS)in the blood routine of the two groups were compared.the differences between absolute eosinophil(EOS)and the incidence and recurrence rate of asthma,and the follow-up of asthma control,nasal symptoms in the two groups after formal follow-up and non-formal follow-up after 1year of follow-up by telephone.There was no statistical difference in the degree of control and the number of acute asthma attacks in the past year.Results: 1.(1)A total of 139 asthma patients were collected,111(79.8%)inthe CARAS group and 28(20.14%)in the SA group;(2)There 53 males and 58 females in CARAS;11 males and 17 females in SA;(3)The average age of the CARAS group was 33.37± 12.250 years and the average age of the SA group was40.29 ± 14.218 years;(4)Of the 139 patients,58(42%)had a long-term occupational history of dust,smoke,coal dust,oil fume,and formaldehyde.2.(1)Of the 111 patients with CARAS,110(99.10%)had rhinitis first;(2)The history of asthma in the SA group was longer than that in the CARAS group(P<0.05);The initial incidence of asthma in the CARAS group and SA group was 61.26% and 25.00%,respectively.The CARAS group had higher incidence of asthma than the SA group;The recurrence rates were 38.74% and 75%,respectively.The CARAS group had lower recurrence rates than the SA group.3.Serum EOS% and EOS expression levels in the CARAS group were significantly higher than those in the SA group(P<0.05).4.There was a positive correlation between AR severity in and AS severity in the CARAS group(r=0.229 p=0.001).5.(1)After 1 year of follow-up,there were 71(64.86%)and 16(58.57%)patients in the CARAS group and the SA group who regularly used asthma drugs;(2)The ACT scores in the CARAS group were better than those in the untreated group,the number of emergency visits and unplanned outpatient visits were lower than those in the non-formally treated group,with significant differences(P<0.05);(3)CARAS group had better control of rhinitis symptoms than in the non-formally treated group,with a significant difference(P<0.05);(4)Of the 139 patients,54(38.85%)were not formally treated.The main reason was that 43% of patients were worried about adverse reactions to the drug,and 37% of patients did not need to continue medication after the symptoms were relieved.Conclusion: 1.CARAS patients are generally young and middle-aged;in theacute attack of asthma,the number of inflammatory cells eosinophils in CARAS patients increases significantly.2.Most patients with AB in Ningxia will have AR,and AR occurs before AS,and AR is positively correlated with the severity of AS.3.A considerable number of CARAS patients in Ningxia are not treated formally.The reasons for non-formal treatment mainly include doctor-patient factors:(1)It is not necessary to continue taking the medicine after the symptoms are relieved,(2)Worry about the adverse reactions of the medicine(mainly glucocorticoids).And adherence to regular treatment helps control symptoms.4.After 1 year of follow-up,the CARAS group has low cognition and poor compliance,and the treatment status is not optimistic.Health education and follow-up management of CARAS patients should be strengthened to improve patient compliance and treatment effect.Only through the joint efforts of both doctors and patients can satisfactory results be achieved.5.This study confirmed the different manifestations of the same disease in different parts of AR and AB from a clinical perspective,emphasizing the early intervention of AR patients and the management of AS patients based on guidelines can effectively control CARAS and improve the quality of life of patients.