Application Of ABM To Study The Effect Of Perioperative Dexamethasone On The Healing Of Surgical Incision

Perioperative low-dose dexamethasone was found to have various advantages such as analgesia and prevention of postoperative nausea and vomiting.We found that dexamethasone caused a change in the amount of cytokine production in the blood of postoperative patients,affecting the healing of surgical incisions.To explore the effects of different doses and different frequency of dexamethasone on postoperative surgical incision healing,we used the Netlogo model development platform to establish an effect of dexamethasone on inflammatory factors and wound healing based on the agent-based model technique.The time-quantitative model qualitatively replicates a wealth of literature data on the healing of skin wound lesions,including the relevant cell populations of T lymphocytes and fibroblasts and their key effector inflammatory factors IL-6 and IL-10.Our ABM reproduces the early changes in perioperative major inflammatory factors and tissue damage under the intervention of dexamethasone.Dexamethasone can significantly inhibit the secretion of pro-inflammatory factor IL-6,promote the secretion of anti-inflammatory factor IL-10,inhibit postoperative tissue damage and promote tissue healing.Different doses and different frequency of dexamethasone can affect the levels of inflammatory factors in early inflammatory injurytissue repair process,but the changes of inflammatory factors in dexamethasone did not make a difference in tissue damage.