Analysis Of Clinical Effect Of Ultrasound-guided Radiofrequency Ablation For Hepatocellular Carcinoma

Objective:To analyze the clinical data of 70 patients who treated with ultrasound-guided radiofrequency ablation of liver cancer in the Department of Hepatobiliary and Pancreatic Surgery of the First Hospital of Jilin University from March 2017 to December 2018.To analyze the efficacy,adverse reactions,and factors affecting the ablation response rate of radiofrequency ablation for liver cancer under ultrasound guidance.To provide a research idea for the best indications of ultrasound-guided radiofrequency ablation in the treatment of liver cancer and increase the ablation rate.Method:A retrospective analysis was performed on the clinical data of 70 patients treated with ultrasound-guided radiofrequency ablation of liver cancer in the Department of Hepatobiliary and Pancreatic Surgery of the First Hospital of Jilin University from March 2017 to December 2018,including preoperative and postoperative radiofrequency ablation.Total bilirubin,alanine aminotransferase,aspartate aminotransferase,albumin,alpha-fetoprotein,history of hepatitis,liver cirrhosis,tumor size,location,number,etc.Using statistical software,single factor analysis was performed using independent sample t-test or non-parametric The test and classification variables were analyzed by the x~2test and other methods to analyze the efficacy,adverse reactions,and factors affecting the ablation response rate of radiofrequency ablation for liver cancer under ultrasound guidance.Result:70 patients with liver cancer underwent RFA for 85 lesions,52 males and 18 females;aged 33-83 years,mean age 59.73±10.21 years,tumor diameter 0.8-5.0cm,average diameter(2.3±0.91cm),length of hospital stay The average is 7.5(6-9)days;preoperative ultrasound: 57 hypoechoic lesions,12 isoechoic lesions,8 hyperechoic lesions,5 strongly echogenic lesions,and 3 mixed echo lesions;The tumor ablation rate was 86%(60/70)at 1 month after operation.AFP significantly improved after RFA(P<0.05);liver function was temporarily impaired after operation(P<0.05),and there was no statistical difference between reexamination of liver function and preoperative one month after operation(P>0.05);the incidence of peritoneal effusion was related to liver function classification The difference between the groups was statistically significant(P<0.05);postoperative fever was related to the diameter of the lesion,and the difference between the groups was statistically significant(P<0.05);There was no significant correlation between age,gender,hepatitis and cirrhosis,tumor size,location,number,etc.and the remission rate of radiofrequency ablation(P>0.05).A large clinical sample is still needed for further study;The one-year survival rate of patients with single lesion was significantly higher than that of patients with multiple lesions,the difference between the two was statistically significant(P<0.05).Conclusion:Ultrasound-guided radiofrequency ablation for the treatment of liver cancer is a local minimally invasive treatment method with satisfactory efficacy.It has the advantages of high safety,accurate effect,small trauma,fast recovery,fewer complications,short hospital stay,repeatable treatment,etc.It is especially applicable for hepatocellular carcinoma recurrence,liver metastasis,the old and weak,high position,central type and other small liver cancers;It can be used as an effective supplementary treatment for partial hepatectomy.RFA treatment of liver cancer can cause liver damage in the near future,but has no effect on liver function in the long term.Fever after RFA is related to tumor size.Larger,the greater the probability of postoperative fever;the occurrence of peritoneal effusion after RFA is related to liver function,the worse the liver function,the greater the possibility of peritoneal effusion.