| Objective: Hyperthyroidism is a typical psychosomatic disease.Diffuse toxic goiter(Graves disease)accounts for 80%-85% of all hyperthyroidism.The occurrence of hyperthyroidis-m is closely related to emotion.Different personality characteristics and psychological states may be the causes or inducing factors of this disease.This paper,through investigating the personality characteristics and psychological states of patients with heart-liver fire hyperactivity of this disease,and combining with relevant clinical indicators and stress factors,reveals the mechanism of emotional pathogenesis for Graves disease,and provides theoretical basis for disease prevention and targeted clinical psychological intervention and treatment of Graves disease.Methods: Use retrospective research methods.Select 40 patients diagnosed with heartliver fire type Graves disease who meet the inclusion and exclusion criteria,and take the infor med consent as the research object,and at the same time,as far as objective conditions allow,try to achieve the similarity of 40 healthy examinees in the same period As a control group.Borrow Eysenck Personality Questionnaire and State-Trait Anxiety Scale to analyz-e the personality traits and mental status of patients with heart-hepatic Huowang Graves disea-se and 40 healthy examinees;and analyze their correlation with clinical physical and chemical indicator-s.Use SPSS25.0 software for statistical analysis.Results:(1)There was no significant difference in age and education level between the o-bservation group and the control group(P>0.05).(2)The proportions of women in the observ ation group and the control group were 57.5% and 70%,respectively,which were greater than the proportions of men;the difference in gender between the two groups was statistically sign ificant(P<0.05).(3)The average value of the E scale and L scale in the observation group is lower than that in the control group;the average value of the N scale and P scale in the observation group is higher than that of the control group,and the observation group is more extroverted,nervous,and mental than the control group.Good at covering up and using less inner de-fense mechanism.The difference between the observation group and the control group in intr-oversion and extroversion,neuroticism,mental quality and disguise were statistically significant(P<0.05).(4)The average values of state anxiety and idiosyncratic anxiety in the observation group were higher than those in the control group,and the anxiety level and regular anxiety tendency of the observation group were higher than those in the control group.Compared with the control group’s state anxiety and trait anxiety,the difference was statistically significa-nt(P<0.05).(5)Stress factors(cortisol,ACTH)and TSH are negatively correlated with introv-ersion and concealment,and the correlation is significant(P<0.01);positively correlated with neuroticism and mental quality,and the correlation is significant(P<0.01).(6)Stress factors(cortisol,ACTH)and TSH are positively correlated with state anxiety and trait anxiety,and the correlation is significant(P<0.01).Conclusion: Patients with Graves’ disease with hyperactive heart and liver fire are extroverted,neurotic and psychotic.They are not good at disguise and use less inner defense mechanism.The anxiety level and recurrent anxiety tendency under stress are higher than those of the control group.Neuroticism,psychotic personality and anxiety levels are positively correlat-ed with cortisol and ACTH,while introversion and extroversion are negatively correlated with cortisol and ACTH.Serum cortisol and ACTH combined with Eysenck Personality Inven-tory and State-Trait Anxiety Scale can be used as preliminary screening indicators for Graves’ disease.At the same time,according to the changes of serum stress factors,targeted psychological intervention can be carried out on patients with special personality traits to prevent the occurrence of diseases and reduce clinical symptoms. |
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