| Objective:Through this subject,observe the clinical efficacy indexes of Shujin Huoluo Lotion combined with Yishen Jiangu Pill in the rehabilitation period of knee dislocation with multiple Ligament Injuries(KDMLI)ligament reconstruction,and evaluate the application of this Chinese medicine internal and external preparation in The clinical curative effect of KDMLI postoperative rehabilitation period is provided,which provides a clinical basis for accelerating KDMLI postoperative r-ehabilitation,and further supplements and improves the KDMLI standardized diagnosis and treatment systemMethod:This trial is a randomized controlled trial study,using the convenience sampling method.A total of 80 patients,including 42 males,were selected based on the inclusion and exclusion criteria based on the patients after KDMLI reconstruction in the Department of Arthropathy and Osteopathology,the First Affiliated Hospital of Gansu University of Traditional Chinese Medicine from July 2017 to March 2019.,38 females,aged 17-56 years old,with an average age of 38.86 ± 13.37 years old,numbered all enrolled cases according to the order of admission,using random number table method to select a set of random numbers to make the patient number and random number correspond to each other,adopt The random number remainder grouping method is divided into a control group,an experimental group A,an experimental group B,and an experimental group C,with 20 cases in each group.The control group was given routine functional rehabilitation guidance after the operation.The test group was given different treatments on the basis of the control group.Test A was given external application of Shujin Huoluo lotion,test group B was given orally,and kidney C was given benefit.Shenjiangu Pills combined with Shujin Huoluo Lotion were taken orally and applied externally,and drug intervention was conducted according to the test medication rules.No other drugs were given after the drug intervention.The follow-up period was 12 months,which were 3 months and 6 months after surgery.At 12 months,follow-up observation was performed to compare and analyze the knee mobility,Lysholm knee score,visual analogue score(VAS),knee ligament treatment effect evaluation index,and observe and record adverse reactions.By collecting and collating the data of the four groups of patients,Excel software was used to collect and input data,and statistical software SPSS23.0 was used for data analysis.Observation index:Safety assessment was conducted when the study was included:blood routine,urine routine,stool routine,liver function(ALT,AST,TBIL),renal function(BUN,Cr),coagulation five items(PT,APTT)and electrocardiogram.After a course of treatment,the affected knee joint activity,Lysholm knee score,visual analogue score(VAS),evaluation of the treatment effect of the knee ligament and the occurrence of complications were recorded.Data processing Use the Excel software to collect the input data,and use the statistical software SPSS23.0 for data analysisResults1.Comparison of general data and baseline data:The general data of the four groups of study cases and the knee mobility,knee Lysholm score,and VAS score before the first treatment after operation were analyzed,and the differences were not statistically significant(P<0.05)This shows that the general data,knee mobility before the first treatment,knee Lysholm score,and VAS score are balanced and comparable2.Comparison of knee mobility:Compared with the control group,the differences in joint mobility after ligament reconstruction were followed at 6 and 12 months(P<0.05),and The score of each test group was higher than that of the control group,indicating that the internal preparations,external preparations,and combined internal and external preparations all improved the joint function after ligament reconstruction.Compared with the experimental group A and the experimental group B,there were 6 There is a difference in monthly knee joint mobility(P<0.05),and the score of group A is higher than that of group B,but there is no difference at 12 months after surgery(P>0.05),indicating that the topical preparation and the internal preparation are clinically early after ligament reconstruction There are differences in effects,and topical preparations have advantages,but as the clinical rehabilitation follow-up time increases,the clinical effects of the two treatment methods tend to be consistent;compared with the test group C and the test group B and test group A,there are differences in postoperative follow-up periods Statistical significance(P<0.05),and the score of group C is higher than that of groups A and B,indicating that the internal and external preparations have better clinical effects in the near and long term than single internal or external application3.Comparison of Lysholm knee score:Compared with the control group,the Lysholm scores of knee joints were statistically significant(P<0.05)in all time periods of 3 months,6 months,and 12 months after surgery(P<0.05),and were higher than that of the control group The control group showed that the combination of Chinese medicine external application,Chinese medicine internal application,and Chinese medicine internal application external application after KDMLI ligament reconstruction can improve the patient's knee function;treatment group A and treatment B group had statistical significance in 3 months after operation(P<0.05),6 months and 12 months after operation,there was no statistically significant difference between the two groups(P>0.05).At the same time,the treatment group A and the treatment group C were statistically significant at each follow-up time after treatment(P<0.05)Compared with treatment group C,the follow-up time of each postoperative group was statistically significant(P<0.05),indicating that the traditional Chinese medicine oral and external application combined with monotherapy has a better clinical effect,and the external application preparation in the early rehabilitation stage after reconstruction is more effective than the internal preparation Good,the effects of internal and external preparations tend to be the same after 6 months after surgery4.Comparison of VAS scores:The VAS scores of the four groups of patients were statistically significant at each time period of follow-up(P<0.05),indicating that postoperative routine functional rehabilitation guidance,external application of traditional Chinese medicine,oral admini stration of traditional Chinese medicine,and oral application of traditional Chinese medicine can alleviate patients Pain symptoms during rehabilitation exercise after ligament reconstruction;the knee VAS pain scores of the experimental group A,the experimental group C and the control group were statistically significant in each time period after treatment(P<0.05),but the control group Compared with test group B,there was no statistical significance(P>0.05),indicating that this Chinese medicine external application and external application combined oral administration was better than a single Chinese medicine oral preparation in relieving pain during ligament reconstruction after KDMLI;3 months after surgery and 6 after surgery The VAS scores of the control group and the test group B were not statistically significant(P>0.05)compared with the test group A and test group C compared to month 12 months,and between 6 months and 12 months after surgery.The statistical significance(P<0.05)shows that the Chinese medicine external application preparation and the Chinese medicine internal application external preparation have unique advantages in relieving pain symptoms in the long-term of ligament reconstruction5.After treatment in four groups of patients,the overall treatment effect was improved or cured at the 12-month follow-up.Only one patient in group B did not heal,and the number of cured patients in the traditional Chinese medicine external application combined with internal use group was higher than the control group and single use Chinese medicine internal or external preparation group6.Safety observation:No significant adverse reactions were seen during the treatment and follow-up of the patients in the Chinese medicine internal application and external application group,the Chinese medicine external application group and the Chinese medicine internal application group.The symptoms disappeared after the treatment was stopped,suggesting that the Chinese medicine preparations had no obvious toxic and side effectsConclusion:In this study,the combined use of Chinese medicine internal preparations,external preparations,internal and external preparations all improve the clinical symptoms of ligament reconstruction after surgery,and relieve the clinical symptoms of post-exercise pain during rehabilitation period;,The clinical effect of improving joint function is better;the external application of traditional Chinese medicine can improve the joint function in the early stage of ligament reconstruction and rehabilitation,but the combined use of internal and external preparations in the later period of ligament reconstruction and recovery has obvious advantages;Oral preparations have a good effect in relieving pain during ligament reconstruction after KDMLI.The single-use or combined use of this Chinese medicine for internal and external preparations has a good overall effect on rehabilitation after multiple ligament injuries of knee dislocation... |
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