To Explore The Clinical Effect Of Etoposide Combined With Cisplatin (EP) In The Treatment Of Small Cell Lung Cancer And Its Effect On The Expression Of E-cadherin,Vimentin And β-Catenin

Objective To study the effect of etoposide combined with cisplatin(EP)on the expression of e-cadherin,vimentin and β-Catenin in small cell lung cancer.Methods 160 patients with small cell lung cancer admitted to our hospital from March 2017 to April 2019 were selected as the study objects,and divided into EP group and CE group according to different treatment schemes.80 cases in EP group were treated with EP regimen(etoposide combined with cisplatin).80 cases in CE group were treated with CE regimen(etoposide combined with carboplatin).Before and after treatment,the effects of e-cadherin,vimentin,β-Catenin,e-cadherin,vimentin mRNA and CTC were compared.Results The ratio of Cr + PR in the study group was significantly higher than that in the control group(76.25% vs 57.50%).The difference was significant(x2 =6.348,P = 0.012);after treatment,the increase of e-cadherin mRNA expression in the study group,vimentin The decrease of mRNA expression was significantly greater than that of the control group(P)Conclusion EP treatment scheme has significant effect on small cell lung cancer;EP treatment scheme can effectively improve e-cadherin and reduce the expression of vimentin,β-Catenin and e-cadherin mRNA,and increase the expression of vimentin mRNA;significantly reduce the number and count of positive expression of CTC;it may be related to its inhibition of upper skin stromal transformation(EMT).