Study On The Changes Of Antibody Levels After Cerebral Sparganosis Drugs And Surgical Intervention

Objectives:C Cerebral schizophrenia is a severely disabling and even fatal infectious disease of the central nervous system.It manifests as a long-term chronic course in clinical.The IgG titer of Schizophrenia schrenkii antibody was used to find the correlation between the antibody level and clinical manifestations and imaging,to further explore the outcome and evaluation of the efficacy of the disease after surgical intervention.Material and methods:Patients with Manchurian schizophrenia diagnosed in 2013-2018 were divided into two groups: the drug treatment group and the surgical group.Drug treatment of 62 patients,50 mg / kg praziquantel,10-day administration,60-day interval,repeated 3 courses of treatment,2 month,6 months,12 months after the end of the 3 course of reexamination of Schizophrenia IgG Antibody titers,MRI plain scans and enhancement of the skull;35 cases were treated surgically,and MRI plain scans and enhancements of the skull were reviewed at 2 month,6 months,and 12 months after operation.Results:Follow-up for 12 months,both groups had positive serum IgG antibodies to Schizophrenia spp.Before diagnosis,titers were 1: 200-1: 3200,and the outcome of the drug treatment was excellent and the symptoms did not change in 2 months after treatment.Imaging follow-up showed that the location and morphology of the lesions changed,the antibody titer did not decrease significantly,and the antibody titer was ≥1: 400.However,with the continued intervention of the drug,the active lesions disappeared,and the antibody titer continued to decline after 12 months.Trend,antibody titer ≤ 1: 100.Patients with poor outcomes after drug treatment,although the active lesions decreased and the antibody titer slightly decreased,but did not show a significant decrease in titer,and imaging showed that the active lesions had once subsided.The antibody titer was still ≥ 1: 400.Patients whose antibody titer did not turn negative in December after drug treatment.Surgical treatment of patients who completely removed the worm body had an antibody titer of ≤ 1: 100 in February after surgery.Those who did not decrease the antibody titer and maintained a high titer indicated that there were still active lesions.In December,patients with no active intensive lesions had antibody drops Degree ≤ 1: 200,but some patients still have neurological deficits and intractable epilepsy.Surgical treatment of antibody titer decreases and the time to negative is faster than drug treatment.In patients with new symptoms or intensive lesions after surgery,antibody titers did not decrease or increase and remained at ≥1: 400.Conclusions:Evaluation of the efficacy of antibody titers in patients with schizophrenia of the brain can further compensate for the limitations of single imaging.Short-term efficacy in 12 months: clinical symptoms are reduced or disappeared,and the antibody titer of patients with no active intensive lesions within 12 months after operation is considered to be a clinical cure.The clinical symptoms did not change or worsened or new symptoms appeared.Although the imaging active lesions subsided but the antibody titer was still ≥1: 400,it indicated that the worms were not completely removed,and the emergence of new lesions must be followed up.Patients with superior outcomes in surgical intervention lost their antibodies earlier than patients with superior drug intervention.