Clinical Analysis Of Dexamethasone Sustained Release Combined With Vitrectomy In Young Patients With Retinal Detachment Accompanied By Inflammatory PVR

Objectives:To observe the clinical effect of dexamethasone sustained release combined with vitrectomy on young patients with retinal detachment accompanied by inflammatory PVR.Methods:Forty-six patients with retinal detachment?10-30 years old?admitted to our hospital from January 2019 to October 2019 in our hospital were selected as PVR D grade^[1]patients,and their vision and eyes were corrected before surgery.Check the thickness of the fovea.According to the specific wishes of the young patients,they were divided into a drug injection group and a control group.The control group underwent routine vitrectomy,and the drug injection group underwent dexamethasone sustained-release implant implantation combined with vitrectomy,of which the drug injection group accounted for 21 There are 25 people in the control group.The follow-up time was 6 months,and the postoperative treatment effect,PVR incidence,ME degree,visual acuity improvement,and anterior chamber inflammation,high intraocular pressure and other complications were compared and analyzed between the two groups.Results:There were no significant differences in preoperative corrected visual acuity,iop or contralateral normal macular fovea thickness between the two groups of young patients with rhegma and grade D PVR?P>0.05?,and the two groups could be compared and analyzed.1?Best corrected visual acuity?BCVA?:The corrected visual acuity of the drug injection group and the control group improved at 1 month after operation compared with that before the operation;while the contrast analysis of the corrected vision of the drug injection group and the control group at 1 month after operation,no significant difference was found.,Not statistically significant?P>0.05?.2?Surgical treatment effect:The effective rate?attained anatomical reduction rate?of the drug injection group and the control group accounted for 85.7%and56.0%respectively after 6 months,and there was a significant difference between the groups?P<0.05?.3?PVR incidence:The incidence of PVR in the drug injection group was 9.5%,and the incidence of PVR in the control group was 36.0%.There was a significant difference between the two groups?P=0.036,P<0.05?,which was statistically significant.4?Degree of macular edema?ME?:The degree of macular edema?ME?in the drug injection group compared with the control group was significantly different at1mo and 3mo after surgery(P=0.008,P<0.05;P<0.01.There was no significant difference in the thickness of ME at 1w postoperatively?P=0.419,P>0.05?;the thickness of macular edema in the drug injection group and the control group after 3months showed a downward trend.5?Complications?anterior chamber inflammation,high intraocular pressure?:?1?Anterior chamber inflammation:The incidence of anterior chamber inflammation in the injection group was superior to the control group,which was 23.8%and 52.0%,respectively.?P=0.031,<0.05?;?2?High intraocular pressure:There is a significant difference in the incidence of high intraocular pressure between the injection group and the control group?P=0.021,<0.05?,high intraocular pressure The incidence rate was 61.9%,while the control group was 28.0%.Conclusions:For young patients with retinal detachment accompanied by inflammatory PVR,dexamethasone sustained release combined with vitrectomy is generally superior to vitrectomy alone.