Clinical Study On Gengnianfang In The Treatment Of Menopausal Syndrome With Liver And Kidney Yin Deficiency

Objective: To observe the clinical effect of Qingrexuexiaoxue Decoction on vaginal bleeding after lng-IUS ring placement,so as to provide effective treatment for vaginal bleeding after LNG-IUS ring placement.Methods: Choose between January 2019 and September 2019,see a doctor in the hospital of Shanxi Province into standard blood hot clip stasis type LNG IUS-120 patients with vaginal bleeding after buy ring,according to random number table method was divided into experimental group and the control group(n = 60),experimental group oral heat stop bleeding soup(exemption decoct Chinese traditional medicine,drug particles water 300 ml,in group 1 day begins to points taken twice in the morning and evening,oral 20 days in a row,drug withdrawal for 10 days for 1 cycle)treatment,the control group oral flexor screw ketone ethinylestradiol piece(1 day to start taking into the group,a morning daily oral 1piece,oral 21 days in a row,withdrawal after a week to start the next box,oral 28 days for 1cycle)treatment.The duration of hemostasis after treatment,changes in TCM syndrome score,endometrial thickness,serum VEGF level before and after treatment,recurrence rate of abnormal bleeding after drug withdrawal and efficacy satisfaction were observed for patients in the two groups after 3 months of medication,and the efficacy of Heat-clearing hemostatic decoction was comprehensively evaluated.Results:(1)baseline data evaluation: there were no significant differences between the two groups in age,course of disease,pregnancy,cause of upper cycle,marriage,culture,occupation,total score of TCM syndromes,score of single symptom,degree of disease,endometrial thickness and serum VEGF levels before treatment(P > 0.05),indicating a balanced comparability.(2)Comprehensive clinical efficacy evaluation: the effective rate was 87.27% in the experimental group and 73.47% in the control group.There was no significant difference between the two groups(P > 0.05),indicating that the two groups had the same drug efficacy.(3)Evaluation of TCM syndromes: The total score of TCM syndromes in the two groups was significantly different from that before treatment(P < 0.05),indicating that drugs in both groups could improve TCM syndromes.After treatment,it was 4.38±3.85 in the experimental group and 6.20±4.65 in the control group.The difference between the two groups was significant(P < 0.05),indicating that the experimental group was significantly better than the control group in improving TCM syndrom.(4)evaluation of hemostasis time: the hemostasis time was 2.00 ± 1.76 in the experimental group and 1.94 ± 1.85 in the control group.There was no significant difference between the two groups(P > 0.05),indicating that the two groups had similar efficacy in improving bleeding.(5)Efficacy evaluation of single symptom: The scores of each single symptom in the two groups were significantly different from those before treatment(P < 0.05),indicating that both groups of drugs can improve the symptoms of patients;After treatment,there was no significant difference in bleeding color and texture between the two groups(P > 0.05),indicating that the two groups were equally effective in improving bleeding color and texture.The scores of fever,dry mouth,cold drink,upset,urination and constipation were significantly different among the groups(P < 0.05),indicating that the experimental group was significantly better than the control group in improving individual symptoms.(6)evaluation of endometrial thickness: endometrial thickness in the two groups decreased compared with that before treatment,but the difference was not significant(P >0.05),indicating that there was no significant effect in improving endometrial thickness in the two groups.(7)VEGF level evaluation: Compared with that before treatment,VEGF level in the two groups was significantly different(P < 0.05),indicating that both groups could improve VEGF level.After treatment,it was 57.81 ± 14.12pg/ml in the experimental group and74.43 ± 4.48pg/ml in the control group.The difference between the two groups was significant(P < 0.05),indicating that the experimental group was significantly better than the control group in reducing VEGF level.(8)abnormal bleeding evaluation: three months after the end of treatment in both groups,patients abnormal bleeding occurred again for 2 people recurrence(3.63%),the control group of 8 people recurrence(16.33%),two groups of data comparison,there are significant difference(P < 0.05),suggesting that the patients bleeding in reducing the recurrence rate is better than that in control group.(9)Evaluation of efficacy satisfaction: the bleeding time was corrected after treatment in both the experimental group and the control group,and the efficacy satisfaction was89.09% in the experimental group and 83.67% in the control group.There was a significant difference between the two groups(P < 0.05),indicating that the experimental group was significantly better than the control group in terms of efficacy satisfaction.(10)Safety comparison: No abnormal vital signs or adverse reactions such as dizziness and nausea were observed in patients of the two groups during the test period.No obvious abnormalities were observed in routine hematuria and stool and liver and kidney function after the test,indicating that the drugs of the two groups were safe.Conclusion:Qingrexuexiaoxue Decoction has a significant curative effect on vaginal bleeding after the placement of blood-heat and blood-stasis lng-IUS ring,which can shorten the bleeding time,reduce VEGF level and bleeding recurrence rate,improve the efficacy satisfaction,have little influence on endometrial thickness,and have good safety.