The Postoperative Anti-inflammatory Effect Of Dexamethasone Sustained-release In Patients With Ocular Trauma Undergoing Vitrectomy

ObjectiveTo explore the anti-inflammatory effects of dexamethasone sustained-release combined with vitrectomy in treatment of ocular trauma,and to provide a theoretical basis for the anti-inflammatory treatment of ocular trauma of postoperative MethodsA total of 48 cases(48 eyes)of patients with ocular trauma diagnosed in the second affiliated hospital of nanchang university from January 2019 to October 2019 was selected as the research objects.According to the wishes of patients and operation method,divided into group A and group B,group A underwent vitrectomy combined with dexamethasone sustained-release implant,group B with underwent vitrectomy.Both groups of patients with preoperative line BCVA,IOP,front camera,fundus camera,slit lamp ophthalmoscopy examination,etc.Analysis and postoper-ative follow-up of 6 months,BCVA,the incidence of proliferarive vitreoretinopathy,anterior chamber inflammation and related complications.ResultsTwo groups of patients' gender,eye don't,age,course of the disease,preoperative IOP and BCVA were no significant differences(P > 0.05).Two groups can be carried out comparative study.1.Best corrected visual acuity(BCVA)changes:Two groups of patients with preoperative and postoperative BCVA difference at different time points(F = 16.404,P < 0.01),and a significant change over time,BCVA is no statistical difference between the two groups(F = 1.060,P = 0.308),Two groups of interactions with the time is statistically significant(F = 9.079,P < 0.01);By t test each time point between the two groups of BCVA results showed that the two groups of patients with preoperative and postoperative 1 day,1 week after BCVA compare had no significantdifference(P > 0.05),June 1 month after operation,postoperative BCVA compare all have significant difference(P < 0.05);group A and B respectively in the two groups of different time points compared two results showed that both groups in the preoperative and postoperative 1 day,1 week after operation,between January and June BCVA difference was statistically significant(P < 0.05),the two groups after surgery between January and June postoperative BCVA was no statistically significant difference(P > 0.05).2.The incidence of Proliferarive Vitreoretinopathy(PVR):A,B two groups the incidence of preoperative PVR were 40.0 % ?39.1 %,there was no statistically significant difference(P = 0.951 > 0.05),A,B two groups in the incidence of postoperative PVR in June were 16.0 %? 60.9 %,which was statistically significant.(P = 0.001,< 0.05).3.The classification of the inflammatory response in the anterior chamber: there was no significant difference in two groups of preoperative anterior chamber reaction(P > 0.05),the two groups of postoperative 1 month of anterior chamber reaction exists significant difference(P < 0.05);Group A in preoperative and postoperative anterior chamber reaction exists significant difference(P < 0.05),there was no significant difference in the preoperative and postoperative anterior chamber reaction in group B(P > 0.05).4.Complications: There was 1 case of dexamethasone sustained-release moving into anterior chamber in group A;there was no complications such as endophthalmitis in two groups of patients after surgery;Two groups of patients with postoperative systemic adverse reactions(such as upset stomach,nausea,vomiting,etc.):1 case of group A,group B 8 cases;Group A postoperative incidence of high intraocular pressure is 72.0 %,Group B is 26.1 %,postoperative incidence of high intraocular pressure differences between the groups was statistically significant(P < 0.05).ConclusionsIn the treatment of ocular trauma,dexamethasone sustained-release in vitrectomy postoperative has good anti-inflammatory effects.