| Objective:To observe the clinical efficacy and safety of Jianpiyishen acupuncture combined with chinese medicine in the treatment of Spleen and kidney Qi Deficiency Chronic Nephritis.Methods:In this study,72 patients with spleen-kidney-qi deficiency type chronic nephritis who met the requirements were included in the outpatient department and inpatient department of Yangpu District Chinese Medicine Hospital.The study cases were included from May 2018 to January 2019.According to the random principle,the patients were divided into 36 patients in the treatment group and 36 patients in the control group.The treatment group was treated with acupuncture combined with oral Chinese medicine Shipi Gushen Huayu Fang.Only oral spleen Shipi Gushen Huayu Fang treatment,the course of treatment is 8 weeks.The therapeutic effects of the TCM syndrome scores and urinary protein quantification,creatinine(SCr),e GFR(EPI formula),blood urea nitrogen(BUN),urine protein/creatinine,alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were observed at 0,4 and 8 weeks in the two groups.Changes in safety indicators such as white blood cells,platelet counts,and hemoglobin at 0 and 8 weeks of treatment.Results:1.Comparison of clinical efficacy:(1)After 8 weeks of treatment,the total effective rate of clinical treatment was 97.22% in the treatment group and 96.97% in the control group.There was no significant difference between the two groups(P>0.05).(2)After 8 weeks of treatment,the creatinine of the two groups was improved(P<0.05).There was no significant difference between the two groups after 4 weeks and 8 weeks(P>0.05).(3)After 4 weeks of treatment,there was no significant difference in TCM syndrome scores between the two groups(P>0.05).After 8 weeks of treatment,the TCM syndrome scores of the treatment group and the control group were improved compared with those before treatment(P<0.05).The difference was statistically significant(P<0.05),suggesting that the treatment group was better than the control group.2.Comparison of observation indexes:(1)After 4 weeks of treatment,there was no significant difference in 24-hour urine protein between the two groups(P>0.05).After 8 weeks of treatment,the urine protein levels in the treatment group and the control group were significantly decreased(P<0.05).The difference was statistically significant(P<0.05),suggesting that the treatment group was superior to the control group.(2)After 8 weeks of treatment,the creatinine of the two groups was improved before treatment(P<0.05).There was no significant difference between the two groups after 4 weeks and 8 weeks(P>0.05).(3)After 8 weeks of treatment,the urea nitrogen in the treatment group was significantly improved compared with that before treatment(P<0.05).There was no significant difference between the control group and the pre-treatment group(P>0.05).After treatment for 4 weeks and 8 weeks,the treatment group was treated with urea.Nitrogen was significantly improved compared with the control group,and the difference was statistically significant(P<0.05).(4)There was no significant difference in e GFR between the two groups after treatment for 4 weeks and 8 weeks(P>0.05);(5)After 8 weeks of treatment,the urine protein/creatinine of the treatment group was significantly lower than that before treatment,the difference was statistically significant(P<0.05),while the control group was not improved before treatment(P>0.05).The improvement was more significant than the control group(P<0.05).3.There were no endpoint events or serious adverse events in either group.Conclusion:1.Jianpi Yishen acupuncture combined with chinese medicine can significantly improve 24-hour urine protein quantitation,urea nitrogen,urine protein/creatinine in patients with Spleen and kidney Qi Deficiency Chronic Nephritis,and Improve the quality of life of patients;2.Jianpi Yishen acupuncture combined with chinese medicine can improve clinical symptoms and improve TCM syndrome scores;3.Jianpi Yishen acupuncture combined with chinese medicine is safe and has no obvious side effects.The therapeutic effect and advantages of traditional Chinese medicine are obvious,and it can be studied deeper and more extensively.4.There are still some shortcomings in this study.The sample size is less and the research time is shorter.It is expected that the next step can be as long as possible to study large samples and improve the clinical research results. |
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