Continuous Veno Venous Hemofiltration Improves The Clinical Prognosis Of Severe Acute Pancreatitis With Sepsis

Objective: Continuous veno-venous hemofiltration(CVVH)was used to treat severe acute pancreatitis in the Department of critical medicine Pan creatitis(SAP)patients with sepsis were treated in early stage.The physiological and biochemical indexes of early CVVH in SAP patients with sepsis were studied,and the clinical effect of early CVVH in SAP patients with sepsis was discussed,so as to provide effective treatment for SAP patients with sepsis,reduce mortality and improve prognosis.Methods: A retrospective study was conducted to collect 62 SAP patients with sepsis admitted to Intensive Care Unit patients,Affiliated Hospital of Youjiang Medical College for Nationalities from January 2014 to September 2019.According to whether the patients received CVVH,they were divided into two groups: CVVH group(38 cases)and control group(24 cases).The clinical data of CVVH group(38 cases)and control group(24 cases)were recorded in detail and analyzed statistically.Results:(1)After treatment,the pulse,respiration,blood amylase and urine amylase levels of the two groups were lower than before,and the changes of pulse,respiration,blood amylase and urine amylase levels of CVVH group and control group before and after treatment were statistically significant(P < 0.05).(2)After treatment,the levels of creatinine and potassium in CVVH group decreased,the levels of sodium and calcium in blood increased,the levels of creatinine,sodium,potassium and calcium in blood in control group increased,and there was statistical significance between the two groups(P < 0.05).(3)After treatment,the levels of aspartate aminotransferase and lactate dehydrogenase in the two groups were lower than those before treatment,and the level of lactate dehydrogenase in thecontrol group before and after treatment was statistically significant(P < 0.05).(4)After treatment,APACHEⅡand Ranson in the CVVH group decreased compared with that before treatment,while APACHEⅡand Ranson in the control group increased compared with that before treatment.The comparison between the two groups showed that the changes of APACHEⅡand Ranson before and after treatment were statistically significant(P<0.05).(5)The length of stay in CVVH group was shorter than that in the control group,and there was significant difference between the two groups(P < 0.05).Conclusion: The results of this study show that the therapeutic effect of CVVH on SAP patients with sepsis is significantly better than that of the control group.CVVH group can effectively improve the physiological and biochemical indexes,improve the clinical symptoms,protect the kidney and other important organ damage,maintain the water electrolytic balance of the internal environment,shorten the length of stay of patients,which has a certain positive significance for the prognosis of patients.