| Objective:Based on the literature study of the etiology and pathogenesis of gouty arthritis,through the development of clinical experiments,to observe the clinical efficacy and safety of "shentongling No.1" in the treatment of acute gouty arthritis with damp heat accumulation syndrome.Method:In this study,a total of 50 cases meeting the inclusion criteria were collected and randomly controlled open trial design was adopted.Through the random number table,25 cases in the trial group and 25 cases in the control group were divided.The patients in the experimental group were treated on the basis of the treatment in the control group,and the patients in the experimental group were treated with the "shentongling No.1" prescription of the tutor's experience.The experimental group and the control group were treated with different methods for 14 days.The clinical effects were observed before treatment,on the 7th day after treatment and on the 14 th day after treatment.The main clinical symptoms and signs,TCM syndrome score,improvement of laboratory indexes,adverse reactions and cases of the two groups were recorded.The efficacy and safety of the two groups were observed before and after treatment Evaluation,using spss25.0 statistical software for data analysis,according to the data results to summarize the clinical efficacy.Result:1.There was no serious heart,cerebrovascular and other diseases in the two groups,and there was no significant difference in gender and age,which was comparable.In terms of clinical efficacy,14 days after treatment,the efficacy of both groups reached 100%.However,the experimental group's significant efficiency and progress rate were better than the control group.2.The curative effect of TCM syndrome was compared.After one week of treatment,the effective rate of the experimental group was higher than that of the control group,and there were no cured patients in the two groups.After two weeks of treatment,the cure rate ofthe two groups was 40% and 8%,respectively,and the difference was statistically significant(P < 0.05).3.In the comparison of joint pain score(VAS score)between the two groups,there was statistical significance between the two groups after treatment(P < 0.05),and there was no interaction between time and group.The pain relief time of the experimental group was significantly shorter than that of the control group(P < 0.01).4.After 14 days of treatment,the tenderness,swelling,activity and thirst degree of the joint in the experimental group were significantly improved(P < 0.05),and the swelling and thirst degree of the joint had obvious advantages after 1 week of treatment(P < 0.05).There was difference between the two indexes of skin color and skin temperature before treatment,and the comparative value was not convincing at this time.There was no significant difference between the two groups(P > 0.05).There was significant difference between the two groups(P < 0.05)no matter after one or two weeks of treatment,and there was no interaction between time and groups in each time period,indicating that the syndrome integral of the experimental group was better than that of the control group in the whole process of treatment.5.In CRP and UA,the improvement effect of the experimental group was better than that of the control group(P < 0.05).In ESR,there was no significant statistical difference between the two groups(P > 0.05),but the slope of the experimental group was larger than that of the control group.It can be seen from this that the ESR decline level of the experimental group after treatment was higher than that of the experimental group,and the experimental group had a slight advantage in improving ESR indicators.6.During the treatment,all patients' vital signs,urine routine,liver and kidney function were normal.There were 5 adverse reactions in the experimental group and 6 in the control group.The experimental group was slightly better than the control group.The adverse reactions of the two groups were mild and similar to gastrointestinal reactions.Conclusion:1.This study is based on the empirical formula "shentongling No.1" established by the tutor with the method of "clearing away heat,detoxifying and turbidity" to treat the patientswith acute gouty arthritis with damp heat accumulation syndrome,"shentongling No.1" has a clear clinical effect.2."shentongling 1" combined with nonsteroidal anti-inflammatory drugs is significantly better than single nonsteroidal anti-inflammatory drugs in improving joint pain,joint tenderness,swelling,activity,thirst and pain relief time.3.In the laboratory index,"shentongling No.1" can reduce the CRP and UA level of patients,and can slightly reduce the ESR level.4.In terms of safety,the combination of traditional Chinese medicine decoction and damp heat accumulation syndrome of gouty arthritis can slow down the adverse reactions of NSAIDs,which is more safe.However,adverse reactions also occurred between the two groups,which should be paid attention to.Further study is expected to minimize adverse reactions and ensure clinical safety. |
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