Influence Of Laparoscopy And Open Surgery On Stress Response And Surgical Effect In Patients With Colorectal Cancer

Objective To explore the effects of laparoscopic surgery and open surgery on the stress response and surgical results of patients with colorectal cancer.Methods Selected colorectal cancer patients who met the requirements in our department in recent years were selected as the observation objects.The laparoscopic surgery group(observation group)and the open surgery group(control group)were taken respectively,and the following related indicators were compared and analyzed:operation time,intraoperative Bleeding volume,postoperative exhaust time,postoperative hospital stay;white blood cell count,C-reactive protein,interleukin-6,procalcitonin;anus preservation rate;surgical resection specimen length,lymph node dissection number,distance of distal resection margin;postoperative Bleeding,incision infection,lung infection,anastomotic leakage or anastomotic stenosis;local recurrence,incision implantation,distant metastasis,postoperative intestinal obstruction,postoperative 5-year survival rate.Results The operation time of the observation group was significantly higher than that of the control group,and the difference was statistically significant(p<0.05);compared with the control group,the observation group had less intraoperative bloodloss,earlier postoperative exhaust time,and less postoperative hospital stay.There is statistical significance(p<0.05).The preoperative white blood cell count,C-reactive protein,interleukin-6,and procalcitonin levels were not significantly different between the two groups of patients(P>0.05).However,the two groups showed an increase in the first day and the third day after surgery.Decreased state,the white blood cell count level of each group of patients on the first day after surgery was significantly higher than that before surgery,the difference was statistically significant(p<0.05),and the white blood cell count level on the third day after surgery was significantly lower than that on the first day after surgery.The difference was statistically significant(p<0.05),but there was no significant difference compared with preoperative(P>0.05).The levels of C-reactive protein,interleukin-6,and procalcitonin on the third day after surgery were significantly lower than those on the first day after surgery(p<0.05),but were significantly higher than those before surgery,and the difference was statistically significant(P<0.05).In the comparison between the 1st day after the operation and the 3rd day after the operation,the level of white blood cell count,C-reactive protein,interleukin-6,and procalcitonin in the observation group were significantly lower than those in the control group,and the difference was statistically significant(p< 0.05).There was no statistical difference in the total anus preservation rate between the two groups(p>0.05),while in the group where the lower edge of the tumor was(5-7)cm from the anus,the observation group had a significant anus preservation rate in the control group,and the difference was statistically significant(p<0.05)).There was no statistical difference between the two groups of patients in the length of surgically resected specimens,the number of lymph node dissections,and the distance of the distal resection margin(p>0.05).The total incidence of recent complications in the observation group was 18.3%,and the total incidence in the control group was 30.0%.The difference was notstatistically significant(p>0.05).In the comparison of lung infections,the incidence in the observation group was 6.7%.The group incidence rate was 20.0%,and the difference was statistically significant(p<0.05).There was no significant difference between the two groups in the comparison of local recurrence,incision implantation,and distant metastasis(p>0.05);in the comparison of postoperative intestinal obstruction,the incidence of postoperative intestinal obstruction in the observation group was significantly lower than that in the control group.There is statistical significance(p<0.05).The 5-year survival rate of the two groups of patients was higher than 50%,and there was no statistical difference in the survival rate of the same time period(p>0.05).Conclusion Laparoscopic surgery can achieve a radical cure effect equivalent to that of open surgery,and there is no significant difference in the number of lymph node dissections and the distance of the distal resection margin.However,the use of laparoscopic surgery can reduce the amount of intraoperative blood loss and faster postoperative recovery,especially the anus preservation rate within the range of 5-7cm from the lower edge of the tumor to the anus is greatly improved,and it can also reduce the occurrence of postoperative complications.The rate,especially the incidence of adhesive intestinal obstruction,is safe and reliable,and it is worthy of further clinical investigation.