Preparation Of Nano Organic/inorganic Hybrid Materials And Their Applications In Biomedicine

Inorganic nano-materials have excellent physical and chemical properties,such as quantum size effects,small size effects,surface effects,and so on.This makes it have many excellent properties,such as optical properties and thermal properties.In recent years,it has been widely used in drug targeted delivery,optical imaging,photothermal therapy,and environmental protection.However,the stability and biocompatibility of inorganic nano-materials is poor,in order to solve this shortcomings.The organic/inorganic hybrid nano-materials were very necessary,not only to improve the stability and biocompatibility of inorganic nanoparticles,but also to improve the hardness and strength of organic matrix materials and other excellent performance.The application of organic and inorganic materials was improved greatly.In this paper,the monodispersed PMMA seeds were synthesized by dispersion polymerization.Secondly,the PMMA porous microspheres were synthesized by two-step seed swelling.Then,magnetic iron oxide nanoparticles?Fe₃O₄?were formed in-situ in the tunnel and obtain PMMA porous magnetic microspheres.Finally,the PMMA porous magnetic microspheres were encapsulated by DR?PMMA@Fe₃O₄@DR?.The PMMA@Fe₃O₄@DR magnetic microsphere which is encapsulated by DR,it shows better stability than the PMMA@Fe₃O₄ magnetic microsphere.The PMMA@Fe₃O₄@DR can maintain excellent magnetism and adsorption capacity in the bad environment.The zinc oxide?ZnO?@Poly?N-isopropylacrylamide??PNIPAM?organic/inorganic hybrid nanomaterial particles with temperature and pH responsiveness were synthesized by simple radical polymerization in triethylene glycol.The ZnO@PNIPAM has a small size?⁴nm?and excellent fluorescence properties.At the same time,we studied the different fluorescence properties of ZnO@PNIPAM at different temperatures,the acid degradability,and the loading and release of drugs.In addition,the polycarboxybetaine methacrylate?PCBMA?was as a pH-sensitive charge-converting shell,the Zn O quantum dot as a fluorescent core?ZnO QDs@PCBMA?,and doxorubicin?DOX?can be attach on ZnO quantum dots.The drug DOX is released within the physiological pH range of the acidic tumor microenvironment.At the same time,at physiological pH conditions?pH=7.2-7.5?,Zn O QDs@PCBMA can show biocompatibility due to the have not protein adsorption of the zwitterionic polymer shell.After reaching the tumor site,the surface of the protonated carboxyl group density increases,can immediately reverse the surface charge of ZnO QDs@PCBMA,which led to a strong adhesion interaction between ZnO QDs@PCBMA and the tumor cell membrane.It can enhance the therapeutic effect.At the same time,the fluorescence change of the interaction between ZnO quantum dots and DOX were studied.In this paper,organic and inorganic nano-materials were compounded by a effective method.The functionalized organic/inorganic hybrid materials were applied in the fields of environmental protection,bioimaging,and targeted drug delivery.