Research On The Application Of Electrode-assisted Electrospinning Technology In Rapid Hemostasis And Scar Cover

With the rapid development of nanotechnology in recent years,nanofibers have penetrated into every aspect of life.Electrospinning technology is a method for preparing micro-nanofibers based on high-voltage electrostatic field.It has some advantages like simple device,wide application materials,easy modification,large specific surface area and small pore size of fibers,which has become the research hotspot in 21 st century.Electrospinning technology has shown broad application prospects in biomedicine,energy storage,catalysis,environmental management,sensors and so on.In situ electrospinning also overcomes some shortcomings on the premise of giving full play to the advantages of traditional electrospinning technology.Disadvantages like:(1)large volume is not easy to carry;(2)non-orientation of fiber deposition;(3)over-dependence on utility power.In situ electrospinning can be used for treatment at any time in the battlefield,field combat,etc.,and lays a good foundation for the application of electrospinning technology in biomedical fields such as on-site first aid,wound repair and cosmetic fields.?-cyanoacrylate medical glue(NOCA)is a kind of adhesive with high strength,good biodegradability,which forms a dense film under the action of anion and used for the bonding and sealing of various tissues,wounds and surgical incisions.The traditional medical adhesive method has the disadvantages of large dosage and easy adhesion of tissues.In this paper,we propose a hand-held electrospinning device with good fiber-oriented deposition characteristics,which is prepared by installing an auxiliary electrode at the needle of the hand-held electrospinning device to increase the electric field and reduce the divergence angle.A well-oriented NOCA fiber to achieve rapid hemostasis when the liver and kidney are partially removed.Compared with the spraying and the airflow-assisted electrospinning technology,the amount of medical glue in auxiliary electrode group is significantly reduced for the directional deposition of medical glue,thereby significantly reducing the toxic side effects and avoiding the tissue adhesion.The application of electrospun nanofiber membranes in the biomedical field is very attractive.The high specific surface area and porosity make it possible to quickly stop bleeding and promote wound healing.In addition,we also proposed another new hand-held electrospinning device with high integration,hand-held portable,directional deposition,precise adjustment parameters,and in situ electrospinning in this paper.The device was successfully used to prepare poly(styrene)(PS),polyvinylpyrrolidone(PVP),sodium alginate(SA)and polyurethane(TPU),which proved the electrospinning practicality of the device.The device was used to electrospinning a chitosan nanofiber membrane similar in color to the skin to cover the scar.Further we tested the permeability,hydrophilicity of the chitosan fibrous membrane.The test results show that the prepared chitosan fiber membrane can achieve the effect of covering the skin scar.