Smart Silicon-based And Zinc-based Nanoparticles Are Used For Drug Delivery And Enhanced Photodynamic Therapy Research

The complexity,diversity and heterogeneity of tumors seriously affect the effectiveness of clinical cancer treatment.Therefore,in order to improve the therapeutic effect,the current clinical research focus has gradually shifted from monotherapy to combination therapy,and combination therapy is stronger than any monotherapy or its theoretical combination.This paper has carried out the following research for the purpose of enhancing the therapeutic effect of cancer:1.Silicon-based nanoparticle-hollow mesoporous silica spheres were prepared by selective etching.The nanospheres have large volume cavities and rich mesopores.Hollow mesoporous silica spheres grafted with a redox-responsive polymer containing a photosensitizer,and synthesize a novel photodynamic therapy-sensitive smart-responsive nanoparticle PIMA-PEG-Ce6-cyst ammonia@HMSNs loaded with metformin and catalase(RNs).RNs have low cytotoxicity and good biocompatibility.RNs have redox reaction properties that allow for the release of drugs in response to glutathione stimulation at the tumor.RNs improve the hydrophobicity of photosensitizers,and have no drawbacks such as targeting,which enhances the effect of photodynamic therapy.RNs use the hollow mesoporous silica sphere-loaded chemical drugs metformin and catalase in combination with the photosensitizer chlorin e6(Ce6)to achieve a significant superadditive effect.It achieved synergistic treatment with chemotherapy and photodynamic therapy.The effect of the tumor and a significant and effective inhibition of tumor growth.2.The zinc-based nanoparticle ZIF-8 coated with orange-red fluorescent carbon quantum dots was synthesized by a one-step method to form a ZIF-8@C-dots drug transport system.The synthesized ZIF-8@C-dots nanoparticles have good monodispersity and regular morphology.The drug delivery system has a high drug loading rate and a strong drug release capacity.The drug release rate is faster and the release is higher under acidic conditions simulating the tumor microenvironment.And the drug delivery system has excellent fluorescence properties of carbon quantum dots.