Preparation Of Fullerene-Modified Mesoporous Hollow Silica Nanospheres And Its Application In Photodynamic Therapy

Recently, Cancer is one of the leading cause of death down to environmental pollution and other factors, it is necessary to find safer and more gentle treatments for cancer compared with conventional treatments which hace negative effects. Photodynamic therapy (PDT) is one of potential anticancer treatments. There are many factors in the process of PDT, and the photosensitizer is the critical element in all. The ideal photosensitizer should be chemically pure and know composition and have a high quantum yield of singlet oxygen. It is said that fullereneare suitable for application as photosentizers because they are efficient visible-light triplet-sensitizers and their ability to photoproduce singlet oxygen is considerable (95%). But the water solubilization of fullerene is very poor which limite the application. Attempts have been made to overcome the insolubility of fullerene by either introducing water-soluble substituents or mixing the fullerene with solubilizing agents.But it also causes a series of problems and people find it is difficult to design water-soluble and mono-substituted C60derivatives which do not self-aggregate. The aggregation of C6o may lose the ability to produce1O2. Concerning this issue, we fabricated mesoporous hollow SiO2nanospheres (MHSNPs) and grated C6o on it by silane coupling agents, finally we investigate the ability of composite material to produce1O2. The research content and innovative achievements in this paper are divided into the following: (1)By means of using the template of cubic nano-CaCO3, we have successfully fabricated hollow mesoporous SiO2nanospheres with uniform morphology and size is about100nm.(2) We use MPS and APTES respectivly as the silane coupling agents to modify MHSNSs and optimize the amount of silane coupling agents. And on this basis, we fumble the reaction mechanisms and conditions.(3)The generation of1O2was investigated by electron spin-resonance (ESR) as well as a chemical approach. The results show that MHSNSs-APTES-C60has the ability to produce1O2and the quantum yield of1O2was tested to be0.52...