Study On The Synthesis And Sonodynamic Properties Of Manganese Phthalocyanine Complex And Its Nanoparticles

Metal complexes are widely used as anticancer drugs,and traditional chemotherapy has serious side effects.Traditional photodynamic therapy?PDT?/photothermal therapy?PTT?suffers from problems such as low penetration depth of light and potential phototoxicity.Which limits its application.However,due to deeper tissue penetration,higher accuracy,and fewer side effects,sonodynamic therapy?SDT?can break the barriers of photoactivation therapy and becom e an effective alternative.SDT provides a noninvasive ultrasound?US?treatment by activating sonosensitizers and inducing reactive oxygen species?ROS?to damage malignant tissue.In this paper,five phthalocyanine complexes?MnClPc,MnPc,ZnPc,PdPc,and P?OMe?₂Pc?were synthesized.Through the exploration of the properties of complexes in solution such as photophysical,stability,sonodynamic,photodynamic,and photothermal,etc.MnClPc complexes with outstanding properties were screened out,and then encapsulated with human serum albumin?HSA?in an ultrasonic ice bath to form MnClPc@HSA nanoparticles to improve water solubility and biocompatibility.Due to its near-infrared region absorption and paramagnetic transition metal Mn ions,it exhibits excellent optical and magnetic properties.MnClPc@HSA nanocomposite can be used as a Nano-sonosensitizers,which will generate singlet oxygen?¹O₂?under ultrasound and more ROS in the presence of hydrogen peroxide.At the same time,it can be very effective for the tumor site photoacoustic/magnetic resonance dual-mode imaging to track the accumulation of nanoparticles in the tumor,making the MnClPc@HSA nanocomposite potentially potential in the sonodynamic effect of MR/PA dual-mode imaging guidance.