| Objective:The purpose of this study was to compare the clinical efficacy of Chaihu Shugan powder combined with psychological intervention in the treatment of patients with primary liver cancer associated depression.Objective evaluation of the efficacy and safety of the combination of Radix Bupleuri and liver and dispersing the liver with psychological intervention,and to provide a scientific basis for its clinical application.Method:According to the standard of primary liver cancer with the depressive state of the patients with mild and moderate in 60 cases,the treatment group(Chai Hu Shu Gan powder combined with psychological intervention group)30 cases,control group(simple intervention group)30 cases.The control group was carried out by professional psychiatrists.The control group only received psychological intervention therapy in the treatment group on the basis of psychological intervention given oral Chaihushugansan decoction,two group psychological intervention one week 1 times,each time for 30 minutes,a total of 4 weeks.The Hamilton Depression Scale(HAMD-17)assessment of two groups before treatment,2 weeks after the intervention,patients with depression were observed after the change,and to observe the two groups before treatment,patients were observed after the end of the core quality of life scale(QLQ-C30)were observed before and after treatment,blood routine,liver and kidney function,ECG and other safety index.Result:1.Depression Evaluation: two groups before treatment HAMD-17 score difference was not statistically significant(P > 0.05);after 2 weeks of treatment compared with before treatment,HAMD-17 scores did not change significantly in control group,the difference was not statistically significant(P > 0.05),the treatment group HAMD-17 score decreased,the difference was statistically significant(P < 0.05);after 4 weeks of treatment,two groups of scores were lower,control group showed significant difference(P < 0.05),the treatment group more significantly different(P < 0.01),the two groups of treatment group were better than the control group(P < 0.05).2.quality of life core scale(QLQ-C30)score: before treatment,there was no significant difference in QLQ-C30 score between the two groups(P >0.05).After 4 weeks of treatment,the scores of the emotional and cognitive function of the control group were higher than those before the treatment,and the difference was statistically significant(P < 0.05).The treatment group of physical,cognitive and general function score better than before,the difference was statistically significant(P < 0.05),emotional function significantly improved compared with before treatment,the difference was statistically significant(P < 0.01);compared with the control group,the treatment group of body,emotion,the overall function of higher than the control group,the difference was statistically significant(P < 0.05).After 4 weeks of treatment,there was no significant difference in the scores of fatigue and pain in the control group,and there was no significant difference between the two groups(P > 0.05).The fatigue and pain scores in the treatment group were lower than those before treatment,and the difference was statistically significant(P < 0.05),and the score was lower than that in the control group,with a statistically significant difference(P <0.05).3.In the single symptom score after 4 weeks of treatment,only one score in the control group was statistically significant(P < 0.05).The treatment group of insomnia,decreased appetite score was decreased,the difference was statistically significant(P < 0.05),shortness of breath score decreased significantly,the difference was statistically significant(P < 0.01),and insomnia and shortness of breath were lower than control group,the difference was statistically significant(P < 0.05).4.safety assessment: two groups of patients before and after treatment blood routine renal function,blood routine,two routine,ECG indicators were normal,liver function indicators were stable,no significant adverse reactions.Conclusion:Chaihushugansan combined with psychological intervention can relieve depression in patients with primary liver cancer associated with depressive symptoms,compared with simple psychological intervention quick,more significant effect,improve the quality of life of patients to a certain extent,improve the patient’s pain,fatigue,insomnia,loss of appetite and other symptoms,and has high security.Have therapeutic value in treating primary liver cancer related depression,is worthy of clinical application. |
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