Study On The Performance Characteristics And Internal Mechanism Of Sadness In Patients With PMS With Liver-stagnation And Qi Stagnation Syndrome

Objective:Premenstrual Syndrome(PMS)refers to both physical and mental symptoms of recurrent seizures in the luteal phase,including irritability,depression,fatigue,abdominal and limb edema,breast tenderness,headache,etc.[1].Although there is no premenstrual syndrome in the relevant literature of traditional Chinese medicine,there are many similar symptoms.TCM gynecology textbooks are collectively referred to as "the syndrome before and after menstruation"[2].The symptomatic manifestations of PMS are closely related to the pathogenesis of hepatic spasm disorder.Clinically,liver qi stagnation syndrome is the most common[3].At present,the research on the physical symptoms of PMS is relatively abundant,but there are few studies on the mental aspects.The application of psychology technology is relatively insufficient for the research of PMS.Chinese medicine also lacks research on the emotional status of PMS,which limits Chinese medicine.The depth of emotional research.This study applied psychological emotion-induced experimental technique to study PMS patients with liver qi stagnation syndrome from two aspects of psychology and physiology.By analyzing the scores of patients with PMS liver qi stagnation syndrome,the subjective evaluation of each stage was evaluated.Emotional feelings,record and analyze relevant physiological indicators and brainwave data,summarize the clinical manifestations of PMS liver qi stagnation syndrome patients and their feelings of sad ness,and explore the biological mechanism and brain electricity of patients with PMS liver qi stagnation syndrome The changes provide data support for the psychological research of patients with PMS liver qi stagnation syndrome,and provide reference for the study of TCM emotional theory and the prevention and treatment of clinical psychosomatic diseases.Methods:1.Questionnaire methodThis study used the female college students as the research object to issue questio nnaires at school.According to the diagnostic criteria of PMS and liver qi stagnation syndrome and the definition of health in the World Health Org anization,the subjects were grouped into 33 subjects in the PMS group and 24 in the health group.The clinical manifestations of patients with PMS liver qi stagnation syndrome were analyzed using BAI scale,BDI scale,EPQ-RSC questionnaire,ASLEC questionnaire,and health questionnaire.2.Emotional video evoked experimentIn this study,from the emotional video library of the team of Professor Zhou Renlai from the National Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,the video with 5 points of neutral and sad emotions was selected as the material of the subject.The video is about 3 minutes.The experiment was conducted in 1 to 7 days before the menstruation(the luteal phase),and was divided into three stages:resting,neutral video,and sad video.The subjects' subjective emotional scores were recorded at each stage,and the subjective response characteristics of sadness in patients with PMS liver qi stagnation syndrome were analyzed.3.Method of biological mechanism researchIn this study,the blood pressure and saliva of the subjects were collected after resting stage,neutral video and sad video,and the data of skin electrical,heart rate and heart rate variability were collected at various stages using Biopac's MP150 physiological multi-channel recorder.The saliva samples were entrusted to Beijing Huada Protein Re search and Development Center Co.5 Ltd.for detection by ELISA.The detection indexes were cortisol,substance P and a-amylase.The physiological multi-channel data was standardized by Beijing Feiyuxing Electronic Technology Co.,Ltd.,and the returned data were analyzed to explore the peripheral biological mechanism of sadness in patients with PMS liver qi stagnation syndrome.4.Method of brain electricity researchIn the resting stage,neutral video,sad video stage,the 40-lead EEG recording system developed by Ne uro scan Co mpany of the United States was used to collect brainwave data o f patients with PMS liver qi stagnation syndrome,and the EEG indicators included delta wave(0.15?4Hz),theta wave(4?8Hz),alpha wave(8?13Hz),beta wave(13?25Hz),gamma wave(25?100Hz)power,and commissioned Beijing Feiyuxing Electronic Technology Co.,Ltd.Standardized processing was carried out,and the returned data was analyzed to explore the central mechanism of sadness in patients with PMS liver qi stagnation syndrome.Results:1.Clinical manifestationsIn the PMS group,the scores of BAI,BDI,EPQ-RSC,ASLEC,and health status questionnaires were higher than those of interpersonal stress factors,health adaptation factors,somatization-emotional factors,cognitive factors,neuroticism,and disguise.Groups,and in the irritable,irritability,flank,fullness,fatigue,dizziness,palpitations,shortness of breath,nausea,stomach discomfort,waist discomfort,leg discomfort and other items were higher than the healthy group.Patients with moderate PMS had higher scores in BAI and health questionnaire than those with mild PMS,and scored in irritable,chest tightness,shortness of breath,nausea,stomach discomfort,chills,dizziness,dizziness,and drowsiness.Medium is higher than mild PMS patients.2.Characteristics of subjective response induced by sadnessIn terms of the overall dimensions of emotions,the PMS group and the health group showed a significant increase in arousal after watching the sad video.The changes in the overall dimensions of emotions tend to be consistent.In terms of the specific dimensions of emotions,after the PMS group and the health group watched the sad video,the calm scores were significantly reduced,the sadness scores were significantly increased,and the sadness scores at each stage tend to be consistent.The scores of sadness in the PMS group during the resting and sad video stages were slightly higher than those in the healthy group.3.Biological mechani'sm?Blood pressure:After watching the sad video in the PMS group,the diastolic blood pressure was significantly higher than that in the resting phase.At each video stage,the systolic and diastolic blood pressures of the PMS group were slightly higher than those of the healthy group.? Cortisol:The co rtisol content of the PMS group decreased significantly after watching the neutral video,and the decrease was not significant after watching the sad video.The content of cortisol in the PMS group fluctuated less.?P substance:Compared with the healthy group,the P substance content in the PMS group was less changed,and the P substance content in the PMS group in the sad video stage was lower than that in the healthy group.??-amylase:The content of a-amylase in the PMS group was lower than that in the healthy group at rest,neutral video and sad video.?Heart rate and heart rate variability:After watching the sad video,the skin power of the PMS group was significantly increased,the HRV index was mainly decreased,and the VLF and TP were significantly increased.The RR mean,SDNN,RMSSD,NN50,PNN50,LF,LF/HF is significantly reduced.Compared with the healthy group,the PMS group watched the sad video stage.The skin power,RR mean VLF,and TP of the PMS group were higher than those of the healthy group,and the others were lower than the healthy group.4.EEG changesAfter watching the sad video,the power of each band of the two groups was mainly decreased,and caused the activation of more similar brain regions,mainly the power loss of the occipital,parietal and frontal cerebral brain waves,which was expressed as delta.The occipital lobe of the wave,the occipital lobe of theta wave,the bilateral apical ridge,the left frontal part,the whole brain of the alpha wave,the parietal lobe of the beta wave,and the parietal and frontal lobe brain wave power of the gamma wave decrease.In addition,the PMS group also caused the right frontal ridge of the delta wave,and the power of the forehead brain wave of the beta wave and the gamma wave increased.After watching the neutral video,the brain power wave power of the PMS group changed significantly,and there were declining brain regions in each band,and there was no power to increase the brain region.The main activation brain regions are right frontal,parietal,and occipital lobe,which are expressed as the right frontal ridge of the delta wave,the right frontal of theta wave,the parietal and frontal lobe of the alpha wave,and the parietal and occipital power o f the beta wave.Conclusion:The clinical manifestations of patients with PMS liver qi stagnation syndrome are:anxiety symptoms are obvious,there is a tendency to depressio n,and this group of people has irritable irritability,depression,and symptoms of physical discomfort such as gastrointestinal and digestive tract This study supplements the psychological understanding of PMS patients in previous studies.This study found that patients with PMS liver qi stagnation syndrome are highly neurotic,have the characteristics of concealed personality,are easy to hide their emotions,and are more susceptible to more life.The impact of the event.At the same time,this study also found that with the increase of the degree of PMS,the anxiety of the subjects increased,and the degree of depression did not change significantly.The subjective response characteristics of patients with PMS liver qi stagnation syndrome were:under the sorrowful emotional stimulation,the experiment successfully aroused and induced the sadness of patients with PMS liver qi stagnation syndrome,and the grief feeling of this part of the population was higher.The biological mechanism of PMS patients with liver qi stagnation syndrome is:under the sorrowful emotional stimulation,the PMS liver qi stagnation syndrome patients have weak stress response,low baseline stress level,and can not be on the body in the face of stress stimuli.Produces good regulation.Sad emotional stimulation reduced the total tension of the autonomic nervous system in patients with PMS liver qi stagnation syndrome,and the degree of activity of the parasympathetic nervous system was most significantly reduced.The characteristics of EEG changes in patients with PMS liver qi stagnation syndrome were:under the emotional stimulation,the brain activity of PMS liver qi stagnation syndrome was stronger,and the changes of EEG were mainly decreased.After watching the sad video,it mainly caused brain activity in the frontal lobe,occipital lobe,and parietal lobe.When watching the neutral video,the PMS group produced more brain activity,and the changes in EEG were mainly decreased.The main active brain regions were the right frontal,parietal and occipital Compared with the sad video,the PMS group observed that the areas of brain wave decline were similar,which may be due to the fact that PMS patients mistakenly think that neutral emotions are negative emotion videos when they receive emotional stimulation,which is similar to sad emotion stimulation.Brain wave activity.The difference is that when watching the sad video,the rise of the parietal and temporal lobe brainwaves occurs,while the neutral video has no rising band,which may stimulate the PMS liver qi stagnation syndrome more strongly with the sad video.Emotional feelings are related.In summary,this study enriches the understanding of PMS disease,supplements the previous research on the psychological aspects of patients with PMS liver qi stagnation syndrome,and initially explores the internal mechanism of sadness in patients with PMS liver qi stagnatio n syndrome.It enric hes the liver-brain theory of traditional Chinese medicine,and provides some data support for the research of PMS disease and the research of TCM emotions.