A Clinical Randomized Controlled Study Of Abdominal Acupuncture In The Treatment Of Estazolam-dependent Insomnia

OBJECT:By making comparisons with the intakes of Estazolam,rates of Estazolam tapering,scores of PSQI,and changes in BWSQ and SCL-90 results before and after the abdominal acupuncture,and the comparison with regular treatment of drug withdrawal,this study discusses the effectiveness of abdominal acupuncture(AA)on patients of insomnia caused by Estazolam addiction.Meanwhile,a cluster analysis of the F1 factors in SCL-90 results before and after AA is made to investigate the mechanism of AA.METHODS:In this study,a AA group and a control group are randomly chosen.The control group is treated with regular Estazolam withdrawal(REW);the AA group adds AA,thrice a week,to REW.The following data are collected:1,the intakes of Estazolam(recorded before and once in the1st,2nd,3rd,4th and 8th weeks after interventions);2,rates of Benzodiazepinetapering(calculated from records of the previous item),3,PSQI(the paperversion of PSQI is used before and in the 4th and 8th weeks of interventions;4,BWSQ(the paper version of BWSQ is used before and in the 1st,2nd,4th and8th weeks after interventions);SCL-90(SCL-90 is distributed to patients ineach group,and an identical instruction is given to each group for patients tofinish the questionnaire independently before and in the end of the 4th weekafter interventions;the data collected are analyzed intra-and inter-group withSPSS24.0).RESULTS:The results are following:1,the inter-group comparison of Estazolam intake shows no significant difference(P>0.05)in the first week of interventions,but in2nd,3rd,4th and follow-up(done in the 4th week after the end of interventions),the intake of the AA group is significantly lower than(P<0.05)control group,with effects stable in the follow-up.2,the clinical effect of Estazolam tapering of the AA group after four weeks of interventions shows an effective rate of 94.3%(effective=24,ineffective=2,controlled=9),while the same statistics of the control group is 74.3%(E=23,I=9,C=3);the total effective rate of the AA group is significantly higher(P<0.05)than that of the control group.In the follow-up,the effective rate of the AA group is 94.3%(E=24,I=2,C=9),while the control group is 57.1%(E=19,I=15,C=1);the effective rate of the AA group is significantly higher(P<0.01)than the control group.3,the inter-group comparison of BWSQ shows that during and after interventions,the BWSQ scores of both groups are significantly different(P<0.01),with the AA group lower than the control one.The intra-group comparison shows that in the 1st,3rd and 4th of the intervention and the follow-up,the BWSQ scores of the AA group is significantly lower(p<0.05)than that of pre-intervention.the same score of the AA group in the second week of the intervention is not significantly different from pre-intervention(P>0.05).In the second week of the intervention and the follow-up,the BWSQ scores of the control group are significantly different from that of pre-intervention(P<0.05),with the second week score higher and follow-up lower than pre-intervention.4,the inter-group comparison in the fourth week after interventions shows that significant differences(P<0.05)in the total score,sleep quality,time of falling asleep,length of sleep,sleep efficiency,and daytime dysfunction exist between two groups,with the AA group lower than the control group.In the follow-up,the abovementioned items in PSQI of the AA group is significantly lower(P<0.05)than the control group.The intra-group comparison in the 4th week of interventions shows that the abovementioned items in PSQI of the AA group score significantly lower(P<0.01)than that of pre-intervention;the total PSQI of the control group in the4th week of intervention is significantly lower(P<0.05)than pre-intervention.In the follow-up,all items mentioned beforehand of the control group is significantly lower(P<0.05)than pre-intervention.5,The pre-intervention scores of all items in SCL-90 indicate no significant difference(P>0.05)between the AA group and control group,indicating that the two sets of data are comparable.The inter-group comparison in the 4th week of intervention shows that the total scores of SCL-90 and scores of positive factors(somatization,depression,anxiety and other factors)of the AA group are significantly lower(P<0.01)than the control group.CONCLUSIONS:The following conclusions can be drawn from this study:AA has relatively good clinical effects on patients of insomnia caused by Estasolam addiction,as the insomnia is relieved,Estasolam intake is reduced or even eliminated,and daytime syndrome and withdrawal syndrome are controlled.Unlike the simple treatment of Benzodiazepine tapering,patients treated with AA have lower chance of relapse.In the treatment of insomnia caused by Estalozam addiction,AA shows its high efficiency,strong efficacy and long effect,proving itself to be clinically advisable.