| Objective:In order to observe the clinical curative effect of Jiannao Anshen capsule on the treatment of Xin Gan Xue Xu type insomnia patients,analyze its influence on serum neurotransmitters,and explore the possible mechanism in treating insomnia.Methods:In this study,90 cases of insomnia patients meeting the inclusion criteria were randomly divided into 3 groups,each with 30 cases;Among them,patients in Jiannao Anshen capsule group took 3 times a day Jiannao Anshen capsules,5 tablets each time,Zaoren Anshen capsule group patients took 5 tablets Zaoren Anshen capsules and estazolam group patients took 1 tablet estazolam of the half an hour before going to sleep every day.A total of 4 courses of intervention(28 days).observe three groups change of the Pittsburgh Sleep Quality Index(PSQI)scores,TCM syndrome scores,gamma-aminobutyric acid(GABA),and glutamic acid(Glu)before and after the intervention,and through data collection and collation analyzed to assess the improvement of sleep in the three groups of patients.Results:(1)Efficacy Assessment:?Total Clinical Efficacy:After 4 courses of treatment,the total clinical efficacy of Jiannao Anshen capsule group and Zaoren Anshen capsule group and estazolam group was respectively 86.67%,83.33%,90.00%,there was no significant difference between the groups by chi square test(P>0.05).?Efficacy of TCM Syndrome:After 4 courses of treatment,the efficacy of TCM syndrome of Jiannao Anshen capsule group,and Zaoren Anshen capsule group and estazolam group was respectively 93.33%,90.00%,66.67%,there was significant difference between the groups by chi square test(P<0.05).The rank sum test between the three groups were compared:1.Jiannao Anshen group and Zaoren Anshen group:P>0.05;2Jiannao Anshen group and estazolam group:P<0.05;3.Zaoren Anshen group and estazolam group:P<0.05;Description:the efficacy of TCM syndrome of three groups were statistically significant effects and were different,Jiannao Anshen group and the Zaoren Anshen group was similar to improve the TCM symptom but was superior to the estazolam group.(2)Therapeutic Index Evaluation:?PSQI Score:Before treatment,the PSQI factor score and total points in three groups were compared by the one-way ANOVA,there was no significant difference between the groups and they were comparable(P>0.05).After treatment,the PSQI factor score and total points in three groups were no difference between groups after one-way ANOVA(P>0.05).the PSQI factor score and total points in three groups were different by the paired T test before and after treatment(P<0.01).(2)TCM Symptom Score:Three groups had no significant difference in each symptom scores and total scores of TCM syndrome by the one-way ANOVA on pretherapy(P>0.05).After therapy,there was no significant difference between the three groups of patients in the symptoms of difficulty in falling asleep,easy to wake up and forgetfulness after one-way ANOVA(P>0.05),but there was significant difference in reducing symptoms such as dizziness and tinnitus,hot,looking ghastly pale,dry eyes,claw armless and total score(P<0.01).Further use the SNK and LSD methods to perform a pairwise comparison.Among them,comparison between Jiannao Anshen capsule group and Zaoren Anshen capsule group(P>0.05),comparison between Jiannao Anshen capsule group and estazolam group(P<0.05),and Zaoren Anshen capsule group and estazolam group(P<0.05),indicated that Jiannao Anshen capsule group and Zaoren Anshen capsule group was better than estazolam group in improving the patients with dizziness and tinnitus,hot,looking ghastly pale,dry eyes,claw armless,but the effect of Jiannao Anshen capsule group and Zaoren Anshen capsule group are similar.The scores of difficulty in falling asleep,easy to wake up and forgetfulness of the three groups were different in the paired T test before and after treatment(P<0.01),but the scores in dizziness and tinnitus,hot,looking ghastly pale,dry eyes,claw armless of Jiarnao Anshen capsule group and Zaoren Anshen capsule group was significant different(P<0.01),and yet estazolam group(P>0.05).?Laboratory Inspection:Before treatment,the levels of serum GABA and Glu in three groups were compared by the one-way ANOVA,there was no significant difference between the groups and they were comparable(P>0.05).After treatment,the three groups of patients were no difference between groups after one-way ANOVA(P>0.05).The levels of serum GABA and Glu of the three groups was different in the paired T test before and after treatment(P<0.01).(3)Liver and Kidney Function ComparisonThere was no significant difference between the three groups in the level of liver and kidney function before and after treatment by one-way ANOVA(P>0.05);After treatment,the three groups of patients were no difference in the level of liver and kidney function by the paired T test before and after treatment(P>0.05),it was suggested that the liver and kidney function of the three groups were not significantly changed after treatment.Conclusion:1.Jiannao Anshen capsule can reduce the PSQI factor score and total points,and increase the clinical efficacy of insomnia as well as improve the patient's sleep quality;2.Jiannao Anshen capsule can reduce TCM symptoms score of Xin Gan Xue Xu type insomnia patients and effectively improve each symptom of TCM(such as dizziness and tinnitus,hot,looking ghastly pale,dry eyes,elaw armless aspect),give full play to the advantages of traditional Chinese Medicine;3.Jiannao Anshen capsule can increase patients' serum GABA and reduce serum Glu content,and its mechanism of action in treating insomnia may be related to the regulation of GABA and Glu levels;4.Jiannao Anshen capsule Jiannao Anshen Capsule has not found obvious adverse reactions and damage to liver and kidney function in the course of treatment.lt is a reliable and safe method for treating insomnia and is worthy of clinical promotion. |
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