Based On Data Mining, It Explores The Medication Rule Of Famous And Old Chinese Doctors In The Treatment Of Coronary Heart Disease From The Spleen

Purpose: Collecting and screening the prescriptions of treating coronary heart disease from spleen from the medical cases of famous old Chinese doctors.Through the traditional Chinese medicine inheritance assistant system software to establish a database for data mining,analyze the regularity of its prescription for the treatment of coronary heart disease.Meanwhile,the entropy clustering method of complex system was used to find the potential drug combinations.It provides certain data support and reference basis for rational and effective clinical drug use and new drug development research of coronary heart disease.Method: Collecting the medical cases of modern famous old Chinese doctors about the treatment of coronary heart disease from the spleen,which is searching from the CNKI,Weipu,Wanfang database and the library of Liaoning traditional Chinese medicine university.The entropy clustering analysis and association rule analysis of complex systems were carried out by using TCM inheritance assistant platform software.Through the combination of traditional Chinese medicine theory and clinical experience,to analyzes and discusses.Results:1.This subject included a total of 171 medical cases and 178 prescriptions.There are227 species drugs were used which the cumulative frequency of use reached 2459 tim es.Analysis results show that the drug which is used no less than 40 times has 15 fla vors.They are Pinellia ternata,Poria cocos,Salvia miltiorrhiza Bunge,Snake gourd fruit,Lig usticum wallichii,Angelica sinensis,Immature bitter orange,Radix curcumae,Rhizoma acori g raminei and Astragalus membranaceus etc.Hot,sweet and bitter drugs are used the mos t.The main meridians are spleen,stomach,liver and lung.2.Through the organization of law analysis,the commonly used drug pair compatibilitie s are:(1)Pinellia ternata,Ligusticum wallichii;(2)Pinellia ternata,Angelica sinensis;(3)Pinellia t ernata,Poria cocos;(4)Pinellia ternata,Immature bitter orange;(5)Pinellia ternata,Radix curcum ae;(6)Pinellia ternata,Salvia miltiorrhiza bunge;(7)Pinellia ternata,Rhizoma acori graminei;(8)Pinellia ternata,Snake gourd fruit;(9)Ligusticum wallichii,Angelica sinensis;(10)Ligusticu m wallichii,Snake gourd fruit etc.3.Famous old Chinese doctors treating coronary heart disease from the spleen uses the core drugs are:Pinellia ternata,Poria cocos,Salvia miltiorrhiza Bunge,Snake gourd fruit,Ligusticum wallichii,Angelica sinensis,Immature bitter orange,Radix curcumae,Rhizoma aco ri graminei and white atractylodes rhizome.The top 10 of the core combination are:(1)wh ite atractylodes rhizome->Poria cocos(0.89);(2)Ligusticum wallichii,Snake gourd fruit->Pine llia ternata(0.87);(3)Bamboo shavings->Pinellia ternata(0.87);(4)Radix curcumae,Snake go urd fruit->Pinellia ternata(0.87);(5)Ligusticum wallichii,Angelica sinensis->Pinellia ternata(0.82);(6)Pinellia ternata,Ligusticum wallichii->Angelica sinensis(0.82);(7)Pinellia terna ta,Radix curcumae-> Snake gourd fruit(0.81);(8)Pinellia ternata,Angelica sinensis-> Li gusticum wallichii(0.80);(9)Snake gourd fruit->Pinellia ternata(0.80);(10)Pinellia ternata,Ligusticum wallichii-> Snake gourd fruit(0.78).Based on entropy clustering analysis,t here are 11 new prescriptions:(1)Bamboo shavings-Pericarpium citri reticulatae-Poria coc os-Ligusticum wallichii-Carthamus tinctorius;(2)Radix paeoniae alba-Rhubarb-Gun gingerAchyranthes bidentata-Cicada slough;(3)Millet bud-Lotus seed-Radix pseudostellariae-O yster-Huangjing-Baizi kernel-Floating wheat;(4)Codonopsis pilosula-Immature bitter orang e-Pseudo-Ginseng-Rhizoma coptidis-Earth turtle;(5)Oriental wormwood-Coix seed-Almond-Patchouli;(6)Xuanfu flower-Acorus gramineus-Radix curcumae-Yuan zhi;(7)Mulberry para sitism-Eucommia ulmoides-White hyacinth-Rhizome;(8)Aconite-Porus-Asarum-Ephedra-Ali sma-Herba cordata;(9)Pinellia ternata-Rhizoma coptidis-Snake gourd fruit-Trichosanthis-S eaweed;(10)Salvia miltiorrhiza Bunge-Dalbergia wood-Allium macrostemon-Angelica sinen sis-Ligusticum wallichii-Woodlouse-Carthamus tinctorius-Cattail Pollen;(11)Turtle armourSeaweed-Epimedium-Wolfberry-Ligustrum-Prunus.Conclusion: Veteran from the spleen of TCM differentiation of coronary heart disease is multi-purpose the spleen and replenishing qi,promoting blood circulation to remove blood stasis,phlegm and fights,such as drugs,conforms to the characteristics of traditional Chinese medicine to treat,with mist two deficiency syndrome in clinical type,heart vein blood stasis syndrome,phlegm turbidity spleen deficient,glove Yang deficiency syndrome,phlegm heatdisturbing card type has a guiding significance of coronary heart disease diagnosis and treatment,the inheritance of traditional Chinese medicine auxiliary platform system to explore famous old Chinese medicine medication rule and characteristics of the disease diagnosis and treatment is of great significance.