Observation On The Clinical Efficacy Of Jiajianguishen Pills Combined With Traditional Chinese Medicine Cycle Therapy In The Treatment Of Patients With Ovarian Dysfunction

Diminished ovarian reserved is a serious disease affecting the reproductive health of women of childbearing age,which can lead to menstrual disorder or infertility,which has attracted more and more attention in recent years.In recent years,with the change of people's way of life and the aggravation of environmental pollution,the incidence of the disease has also shown a clear upward trend.At present,it is considered that the main causes of this disease are related to age factors,genetic factors,environmental factors,psychological factors,immune factors and surgical trauma of the ovary.Clinical manifestations of diminished ovarian reserved are mainly menstrual disorders(including frequent menstruation,are menstruation or less menstrual volume etc),infertility and some manifestations related perimenopausal syndrome,more patients see doctors due to menstrual changes and infertility.The treatment of diminished ovarian reserved is also developing with the deepening of its understanding.At present,there is no standardized therapeutic regimen for the treatment of diminished ovarian reserved.Modern medicine mainly focuses on hormone replacement therapy,which can maintain menstruation and delay symptoms through the supplement of exogenous hormones.The TCM treatment of diminished ovarian reserved is mainly based on kidney tonifying to syndrome differentiation treatment,in the anti-ovarian aging has a good advantage.JiaJian GuiShen formulation is the experience prescription of Professor Zhang Yuzhen,the third generation descendant of The School of LUO's Gynaecology.The whole prescription has the effect of tonifying kidney and invigorating spleen,soothing liver and activating blood.This formulation is always used clinically for premature ovarian failure and diminished ovarian reserved.Chinese medicine cycle therapy is to choose medicine according to the change regulation of yin and yang,qi and blood in menstrual cycle,regulate yin and yang to regulate menstrual cycle.In order to make clear the therapeutic effect of this treatment method on diminished ovarian reserved,this research subject intends to treat diminished ovarian reserved with JiaJian GuiShen formulation combined with Traditional Chinese Medicine cycle therapy.Objective:By observing the changes of TCM syndromes,serum sex hormone levels and syndromes of spleen and kidney deficiency,liver stagnation and blood stasis type diminished ovarian reserved,the clinical effect of this intervention method on patients with diminished ovarian reserved was evaluated,and the reference was provided for the clinical treatment of diminished ovarian reserved.Methods:In this research subject,40 patients with diminished ovarian reserved of spleen and kidney deficiency,liver stagnation and blood stasis type were selected from Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine.Treatment is based on JiaJian GuiShen formulation,and combined with menstrual cycle,observe those patients 3menstrual cycles(3 months for patients with amenorrhea).Before and after self-treatment,the changes of TCM syndrome,serum FSH?LH?FSH/LH?E2 value and TCM syndrome efficacy score before and after treatment were observed,and the clinical effect of JiaJian GuiShen Formulation combined with Traditional Chinese medicine cycle therapy on patients with spleen and kidney deficiency,liver stagnation and blood stasis type of diminished ovarian reserved was analyzed.Result:(1)Changes of TCM syndrome efficacy score before and after treatment:compared with prior treatment,the TCM syndrome efficacy score in post-treatment was significantly lower than before,and the difference was statistically significant(p<0.05).(2)Serum sex hormone changes before and after treatment:compared with prior treatment,the FSH value of serum sex hormone in post-treatment decrease'd significantly compared with that before(p<0.01).The FSH/LH value of serum sex hormone in post-treatment was lower than that before(p<0.05).The LH value of serum sex hormone in post-treatment was lower than that before(p>0.05).The serum E2 level in post-treatment did not change significantly compared with that-before(P>0.05).(3)TCM syndrome efficacy after treatment:1 case(2.5%)was markedly effective,38 cases(95%)were effective,1 case(2.5%)was ineffective,the total effective rate was 97.5%.Conclusion:JiaJian GuiShen formulation combined with traditional Chinese medicine cycle therapy can improve the clinical symptoms of patients with diminished ovarian reserved,reduce the level of serum sex hormone FSH,and have a good clinical effect on the treatment of patients with spleen and kidney deficiency,liver stagnation and blood stasis type of diminished ovarian reserved.