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Development of new synthetic methodology and approach to total synthesis of (-)-morphine

Posted on:2014-08-12Degree:Ph.DType:Thesis
University:University of DelawareCandidate:Bai, ShaFull Text:PDF
GTID:2451390008952936Subject:Chemistry
Abstract/Summary:
The work presented here is divided into three projects, each with a specific aim. All projects involve new synthetic methods and two of them demonstrate the practical application of Taber laboratory developed synthetic protocols in the total synthesis of natural products. The first project describes the development of an inexpensive and convenient reagent for the one-carbon homologation of an aldehyde to the corresponding alkyne. The developed reagent was much less expensive than the currently available reagents (~...
Keywords/Search Tags:Synthetic
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