| While a number of studies have evaluated exposure matrices for children, limited data are available to define the relationship between gene expression and excretion of organophosphate pesticides (OPs). The primary objective of the present study was to develop preliminary data regarding the relationship between the elimination of organophosphate pesticides and single nucleotide polymorphisms (SNPs) of the paraoxonase enzyme. The specific objectives in this study are to investigate potential sources of exposure to OPs in children, aged 6 to 48 months, based on floor swipe and hand wash samples; monitor elimination of OPs in the children using measurements of organophosphate metabolites in urine; evaluate the frequency of SNPs within the HUMPOMA gene that codes for paraoxonase expression in the populations and investigate the relationship between hand rinse pesticide concentration, PON polymorphisms and the excretion of OPs. (Abstract shortened by UMI.)... |
