The effects of Lamin A/C C1908T polymorphism on body composition, plasma lipoprotein-lipid profile and insulin sensitivity changes with exercise training

Obesity, lipoprotein subclass concentrations and insulin resistance are predictors of cardiovascular disease (CVD). The Lamin A/C (LMNA) C1908T polymorphism has been associated with obesity-related anthropometric and biochemical traits, higher fasting triglyceride, lower HDL-cholesterol concentrations and the metabolic syndrome. Aerobic exercise training has been shown to generate favorable changes in body composition, lipoprotein-lipid profile and insulin sensitivity and to reduce CVD risk. The purpose of this project was to examine the effect of the C1908T polymorphism on percent body fat, plasma lipoprotein-lipid profile and insulin sensitivity in sedentary subjects before, and their change with, 24 weeks of exercise training. Following IRB approval, 144 sedentary adults underwent dietary stabilization, body composition scans, a 3-hour oral glucose tolerance test (OGTT) and plasma lipoprotein-lipid profile analysis. Genotyping was performed using standard techniques. Following baseline testing, 104 subjects completed six months of aerobic exercise training and then underwent a final body composition scan, 3-hour OGTT and plasma lipoprotein-lipid profile analysis. (Abstract shortened by UMI.).