| Phosphine ligands have established their position as one of the most effective ligands for homogeneous transition-metal catalysis. Further application is limited by the lack of knowledge for rational design and time-consuming synthesis for individual ligands. Our approach, through the use of peptide chemistry and parallel synthesis, can allow for the synthesis of a large collection of phosphine ligands with diversified structures. In this dissertation, the design of peptide-based bisphosphine ligand libraries (P, P coordination mode) and the results of palladium-catalyzed π-allyl addition are reported. The chemistry to synthesize β-turn based phosphine-oxazoline ligand libraries (P, N coordination mode) using oxime resin was developed. The investigation of the possible involvement of the carbonyl functional group in the coordination of peptide-based phosphine ligands (P, O coordination mode) is described, and the application of these ligands in kinetic resolution of 1,3-dipropenyl acetate is also reported. |
