| This research attempted to developed materials resistant to device related infection. First, water, ammonia or carbon dioxide plasmas were utilized in a remote microwave plasma (RMP) reactor. Increased hydrophilicity of the surface in water and ammonia plasma treatments was noted. A reduction in colony forming units was noted with water plasma treatment when challenged with Pseudomonas aeruginosa under static flow in the presence of ciprofloxacin.; To illustrate the ability of attaching a drug delivery system activation with primary amines was required with ammonia plasma on ethylene treated polyurethane (optimised separately). An optimum using the RMP plasma was found at 408 sccm, 20 W power and 1 minute.; Attachment of a drug delivery system through primary amine groups was assessed using isocynate chemistry and a commercial fluroalcohol. Surfaces with the activation registered a fluorine signal proving the feasibility of attaching a drug delivery system through this chemistry. |
