| Solubility data for solids in supercritical fluids (SF's) is one of the most important phase equilibrium properties for the design of Supercritical Fluid Extraction and Supercritical Fluid Chromatography (SFC) processes. Due to the large number of pharmaceutical companies in Puerto Rico, the search for effective and environmentally safe specialty separation processes is always of great interest. SF's provide a promising alternative due to their particularly liquid-like densities and gas-like mass transport properties (e.g., ;This research is focused on the development of an experimental chromatographic apparatus in which a packed column is coupled to a high-pressure UV detector to obtain solubility data for solids in supercritical carbon dioxide. Retention measurements in supercritical fluid chromatography were studied for two different systems (CO... |
