Rhodium catalysed tandem hydrosilation cyclisation reaction |
Posted on:2001-04-24 | Degree:M.Phil | Type:Thesis |
University:University of London, University College London (United Kingdom) | Candidate:Mills, Catherine Ellen | Full Text:PDF |
GTID:2461390014956108 | Subject:Organic Chemistry |
Abstract/Summary: | |
Work has begun on defining the scope of a novel tandem hydrosilylation cyclisation reaction as a general method for the synthesis of substituted carbocycles. Part I: Substituted cyclopentanols are accessible from 4-pentenals in moderate yield and cis selectivity. When R=CO2Me, a reversal in selectivity can be effected through the choice of the catalytic system. Part II: This methodology is compatible with 4, 5-substitution of the parent substrate, generating functionalised cyclopentanols in moderate selectivity and good yield. Part III; Tandem hydrosilylation cyclisation chemistry is applicable to the synthesis of substituted cyclohexanols. Conclusion: This novel chemistry provides a simple entry from lactols to highly substituted cyclopentanols and cyclohexanols in moderate yield and selectivity. |
Keywords/Search Tags: | Tandem, Cyclisation, Substituted, Selectivity |
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