Stereocontrolled total syntheses of plasmalogen and diplasmalogen lipids and their activities in an intracellular drug delivery system

Posted on:1997-07-25

Degree:Ph.D

Type:Thesis

University:Purdue University

Candidate:Rui, Yuanjin

Full Text:PDF

GTID:2461390014981778

Subject:Chemistry

Abstract/Summary:

The objective of present study was to develop an efficient chemical synthesis method for the plasmalogen and diplasmalogen lipids and to investigate their potential applications in pH-sensitive liposomal drug delivery systems. A stereo-controlled preparation of cis-vinyl ether linkage was developed using an ester as precursor. At -78...

Keywords/Search Tags:

Plasmalogen and diplasmalogen lipids, Drug delivery

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