| igmentation resulting from synthesis and dispersion of melanin is the major physiological defense against sun-related injuries, including melanomas. However, the detailed mechanisms regulating pigmentation are poorly understood. The cyclic AMP (cAMP)-dependent pathway is thought to play a key role in pigmentation because agents that elevate intracellular levels of cAMP are potent inducers of pigmentation. Among these agents, ;In this study, molecular events regulating pigmentation were further elucidated using Cloudman S91 murine melanoma cells (S91 cells). Treatment of S91 cells with 10;To determine whether inhibition of the cAMP-dependent pathway can block... |
