Construction of Anti-Inflammatory Thiazole-Pyrazole Compounds, Methodology Development for Synthesis of Semiconducting Oligothiophenes, Polymer-Bound Phosphonamide Auxiliaries and Computational Mechanistic Studies of Pseudomonine

This dissertation is constructed into four chapters encompassing the four projects I have worked on while at UC Davis. Three out of the four chapters (chapter one, two and four) all involve organic synthetic methods to design small molecule heterocyclic molecules. Chapter three involves physical organic computational chemistry methods to study a mechanistic transformation.;Chapter one is about the synthesis and subsequent evaluation of biological activities of a variety of prepared thiazole heterocycles. Our goal is to work with UC Davis Medical Center to hinder a novel enzyme-integrin site that triggers an inflammatory response in living organisms.;Chapter two is about methodology development for the synthesis or organoelectronic material that can be anchored to silicon and gold wafers. We collaborated with Lawrence Berkeley National Labs and UC Davis's Gang-Yu Liu group to design oligothiophenes of interest with various functionalities using greener methodologies.;Chapter three involves the mechanistic study of pseudomonine, an isoxazolidonecontaining compound with siderophoric activity from pseudomonas fluorescence, a bacteria found in Lake Victorian Nile Perch in Uganda, Africa.;The last chapter four is about the synthesis of polymer bound phosphonamides using cheaper material, reduced steps, and greener methodologies. Previous research has shown cyclic phosphonamides to have catalytic activity in olefination reactions and we aimed to improve upon that process by building these structures on polymers.