Study On The Structure Of Bionic Three-Dimensional Porous Lattice Scaffold For Artificial Skin

Tissue engineering refers to the research and development of a certain biological substitute and its application in organ and tissue repair by combining the principles of life science and engineering.Among them,the construction of a three-dimensional tissue scaffold is an indispensable link.This kind of tissue engineering scaffold must meet certain mechanical and mechanical performance requirements,and the structure of the scaffold needs to be designed with accurate matching values.Otherwise,the biomechanical properties,geometry,and liquid transmission characteristics of the scaffold structure will have irreversible effects due to changes in the local or overall structure,which will affect the cells implanted in the scaffold.Therefore,the design of scaffolds with good structural morphology and excellent mechanical properties is of great significance to tissue engineering research.This paper proposes a scaffold structure design method that combines the unit cell body and the spatial lattice,namely the three-dimensional porous lattice scaffold structure.A brief overview of the current situation and progress of tissue engineering scaffolds has been made,and the application potential and prospects of three-dimensional scaffolds in tissue engineering medical repair have been analyzed as well.The mechanical properties and energy absorption characteristics of different kinds of three-dimensional lattice structures after uniaxial compression are discussed.At the same time,this paper designs unit cells with different structures and discusses their mechanical properties;based on the unit cells,it constructs 4 three-dimensional porous lattice structures,and adopts light-curing flexible resin materials with specific proportions,through DLP(Digital Light Processing)3D printing technology manufacturing molding.Based on finite element analysis and experimental verification,this paper intends to analyze and compare the characteristics of the designed three-dimensional lattice structure in terms of relative density,structural strength and energy absorption characteristics,and screen out lattice structures with good mechanical properties and study them The mechanical properties of the structure under different parameters.The compressive mechanical properties of the three-dimensional porous lattice structure based on different topological structures are studied.A series of topological three-dimensional lattice structures designed by different single-layer lattice structure arrangements are constructed.And through finite element and experiments,it is verified that the topological lattice structure has better compression and energy absorption characteristics than the ordinary lattice structure.Based on the principle of bionic design,the structural characteristics of the longitudinal section of the skin are analyzed,and the three-dimensional porous lattice structure of the simulated skin is designed according to the characteristics of its relative density arranged from high to low.The structure is compressed and finite element simulation analysis is performed to obtain the final result.Finally,a porous lattice structure with a wider compression energy-absorbing platform is obtained.Meanwhile,it is verified that the three-layer lattice structure designed by density gradient has a wider compressive stress platform than the ordinary three-layer lattice structure.The three-dimensional porous lattice structure studied in this paper has good mechanical properties and compression energy absorption characteristics.The designed flexible porous scaffold can not only be used in the construction of artificial skin in vitro,but also has a certain promotion effect on the design of tissue scaffolds required in tissue engineering.At the same time,it also provides a new guiding idea for the filling design of wearable flexible devices.