Study On The Photothermal Effect Of Mesoporous Silica Anti-tumor Microspheres

CuS is a kind of photothermal materials with low cost and non-toxic.In this project,the CuS nanoparticles were synthesized successfully with near-infrared photothermal response through a novel method.And then,using CTAB as the template and TEOS as the silicon source,the mesoporous silica was wrapped around the copper sulfide nanoparticles,thereby establishing a CuS@MSN drug delivery system.In this paper,a series of TEM,BET,infrared and other tests were performed on CuS @ MSN microspheres,and the composition and surface morphology were judged.A series of in vivo and in vitro studies showed that MSN shell did not obstacle the photothermal effect of CuS,and CuS could rapidly increase the local temperature about 20 degrees in 30 seconds of near-infrared lightening resulting at the tumor collapse rapidly.Meanwhile,CuS would not escape from MSN easily.On the other hand,it was worth to mention that the drug loading system also had the sensitive to respond to the p H of environment.It could not release drugs in acidic and neutral environment,but had a stable release behavior in alkaline conditions.Furthermore,in vivo organ section experiments,it was also shown that the system was safe and harmless to normal tissues and cells except tumor.Therefore,this new drug delivery system of CuS@MSN with the synergistic of p H-sensitive release and photothermal therapy can be structured and applied to tumor treatment in the future researches.