Construction And Biological Molecular Chiral Recognition Performance On Interface Of Calix[4] Arenes Assembled

Chiral is common phenomenon in nature,which is always found in plants,animals or human life.There are a lot of chiral molecules such as amino acids,proteins,DNA,sugar,etc.The different chiral of the same material in living organisms may show the different physiological activity.With people's deeply research,which found that different chiral affects the life activities of the organism.If ignore chirality can bring a safety loophole to people.In recent years,the research of chirality molecule are mainly concentrated on chiral molecular recognition in solutions,which pay little attentions to functional interface for chirality research.In this paper,the first and second chapters based on the basic principle of chiral recognition,and functional calix[n]arene can be designed and synthesized and recognize guests with a certain selectivity and sensitivity based on electrostatic interaction,hydrophobic interaction,hydrogen interaction.Then the lower limb derivative of calix[4]arene have coordination effect with Au by coordination bond.The third chapter of this paper is on the basis of the first two chapters,which proved that chiral paraquat induced chiral helical structure of pillar[6]arene.The specific content of this thesis are as follows:Firstly,according to the structure of glucose,R-mandelic acid hydrazide calixarene molecules(R-C4)was designed and successfully modified to gold surface by acetylene-Au bond to forming R-C4 SAMs;The response of impedance and contact angle demonstrate that R-C4 SAMs can recognize L-glucose with high selectivity.The mode of R-C4 interacting with L-glucose have been studied by Gaussian simulation and 1H NMR.Secondly,according to the structure characteristics of the BSA,calix[4]arene was designed and formed R/S-AC4 SAMs on gold surface by clicking chemistry acetylene-Au.The response methods of contact angle and impedance show that AC4 SAMs can recognize BSA with high selectivity adsorption.The special cavity of calix[4]arene with a certain size and full of electron play a critical role in recognizing BSA.Finally,discuss their gold interface and BSA dynamic change trend with the time changing.Finally,based on the first two chapters in chirality interface influence on biological molecules,can we use chiral molecular structure induced the chiral signal of achiral molecules?Therefore paraquat derivatives d was designed and formed R/S-p SAMs on gold surface by clicking chemistry acetylene-Au.The chiral interface for pillar[6]arene chiral induction,the experimental results show that CD characterization of the chiral interface for pillar[6]arene chiral induction.