Synthesis Of Graphene Supported Bimetallic Alloy Or Their Oxide Composites And Their Performance For Electrochemical Glucose Sensing

Electrochemical glucose sensor is a kind of technique method,which can indirectly or directlyelectrooxidize glucose and detect the concentration of glucose through the electrochemical signals.Nanomaterials have been widely used to constructthe electrochemical glucose sensor due to their good biocompatibility,large specific surface area,high catalytic activity and strong adsorption ability.This thesis puts emphasis upon studies on preparation of new graphene-basednanocomposites by depositingthe bimetallic alloy or their oxide nanoparticles on the reduced graphene oxide(rGO),which is applied in the construction of non-enzymaticelectrochemical glucose sensor with high performance.The sensor preparation and analysis conditions were optimized,and the properties of as-prepared sensors were investigated systematically for glucose detection.The main original results are as follows:(1)The PdMn/rGOcomposite was prepared by depositing PdMn alloy nanoparticles on the rGOsupport via the stirring method,which was used for the fabrication of a novel non-enzymaticelectrochemical glucose sensor(PdMn/rGO/GCE).The physical and electrochemical characterizations of the prepared materials were carried out by X-ray diffraction(XRD),Raman spectroscopy,transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS)and electrochemical tests.The results demonstrate that the fabricated PdMn/rGO/GCE sensor has good electrcataytic activity to glucose oxidation.Under the optimum conditions,the senor exhibits a wide linear range of 0.0161 mM?1.152 mM and 1.152 mM-4.875 mM,a low detection limit of 1.25 ?M(S/N=3)and a low working potential(-0.1V)as well as excellent reproducibility(seven parall determination,reative standard deviation is 5.4%),stability(the amperomertic response can still maintain 85.58%of its initial response current after 20 days)and anti-interference ability(L-arginine,H2O2,uric acid,dopamine and ascorbic acid have no abvious interference to the glucose detection).(2)With the rGO as the support,the NiAgOx/rGO nanohybrid was synthesized using the hydrothermal method,and a novel NiAgOx/rGO/GCE electrochemical glucose sensor was fabricated by modifying this composite on the glassy carbon electrode(GCE).The systhesized nanocomposites were characterized by SEM,TEM,XRD,XPS and Raman.Someelectrochemical techniqueswere used to evaluate the response performance of the prepared sensor toward glucose detection.The results demonstrate that the fabricated NiAgOx/rGO/GCE sensor has good electrcataytic activity to glucose oxidation.Under the optimum conditions,the sensor exhibits a wide linear range of 0.0196?1.388 mM and 1.388?6.464 mM and a low detection limit of 0.65 ?M(S/N=3),fast response(<4s)as well as excellent reproducibility(seven parall determination,reative standard deviation is 4.32%),stability(the amperomertic response can still maintain 81.27%of its initial response current after 20 days)and anti-interference ability(L-arginine,H2O2,uric acid,dopamine and ascorbic acid have no abvious interference to the glucose detection).