Study On Preparation Of Magnetic Micro-nano Particles Based On Multimaterial Fibers

Magnetic micro-nano particles are widely used in cancer targeted therapy,biomolecular screening and other scenarios due to their advantages in manipulation and microsize.So far,the manufacturing methods of magnetic micro-nano particles have the following problems:the particle size and structure cannot be adjusted precisely,extra templates are needed,the preparation process is complicated,and the production efficiency is low.In this paper,we studied a method of manufacturing micro-nano particles based on in-fiber Plateau-Rayleigh instability(PRI).By controlling the structure of the preform,we controlled the structure of the magnetic micro-nano particles in the radial and azimuth.By controlling the diameter of the pulled fiber and the size of the magnetic micro-nano particles,the simple and high-throughput production of magnetic micro-nano particles with precise and controllable structure and size will be possible.The main contents of this paper are as follows:(i)a briefly introduction to magnetic micro-nano particles and Plateau-Rayleigh instability(PRI)as well as the preparation of micro-nanoparticles based on in-fiber PRI;(ii)using the classic Tomotika model to analyze PRI,(iii)describing the process of the development of PRI and the formation of micro-nano droplets through theoretical calculation and computer simulation,(iv)manufacturing structured micro-nano magnetic particles based on in-fiber PRI.The study in this paper can help people better understand PRI,understand its application in the preparation of nano particles,and provide ideas for the manufacturing of fibers and particles doped with functional materials.